所有图片(1)
About This Item
经验公式（希尔记法）:
C18H19NO3S2
CAS号:
分子量:
361.48
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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化驗
≥98% (HPLC)
形狀
lyophilized powder
顏色
white
溶解度
DMSO: ≥30 mg/mL
儲存溫度
2-8°C
SMILES 字串
CCOC(=O)C1Cc2ccccc2CN1C(=O)c3ccc(SC)s3
InChI
1S/C18H19NO3S2/c1-3-22-18(21)14-10-12-6-4-5-7-13(12)11-19(14)17(20)15-8-9-16(23-2)24-15/h4-9,14H,3,10-11H2,1-2H3
InChI 密鑰
UIEBLUZPSFAFOC-UHFFFAOYSA-N
應用
SR8278可用作rev-erbα拮抗剂，研究胰高血糖素分泌对小鼠胰岛α细胞和β细胞的调节作用。
SR8278已被用作核受体亚家族1D组成员1（NR1D1）拮抗剂，以研究其对饥饿诱导的巨噬细胞的作用。
生化／生理作用
SR8278是核血红素受体REV-ERB拮抗剂。REV-ERBα通过抑制靶基因活性在调节昼夜节律中起关键作用。另外，研究表明，REV-ERBα可调节脂质和葡萄糖代谢等代谢过程。 SR8278可阻断合成激动剂GSK4112增强REV-ERBα依赖性抑制的能力、刺激参与糖异生的REV-ERBα靶基因的表达。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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