S8201
SR-3576
≥98% (HPLC)
别名:
3-(5-(3-m-Tolylureido)-1H-indazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide, 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide
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所有图片(1)
About This Item
经验公式（希尔记法）:
C27H27N5O5
CAS号:
分子量:
501.53
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
表单
powder
颜色
light brown to brown
溶解性
DMSO: ≥20 mg/mL
储存温度
2-8°C
SMILES字符串
COc1cc(NC(=O)c2cccc(c2)-n3cc(NC(=O)Nc4cccc(C)c4)cn3)cc(OC)c1OC
InChI
1S/C27H27N5O5/c1-17-7-5-9-19(11-17)30-27(34)31-21-15-28-32(16-21)22-10-6-8-18(12-22)26(33)29-20-13-23(35-2)25(37-4)24(14-20)36-3/h5-16H,1-4H3,(H,29,33)(H2,30,31,34)
InChI key
MTFAYLZZDJGFGV-UHFFFAOYSA-N
应用
SR-3576 may be used in JNK3-mediated cell signaling studies.
生化/生理作用
SR-3576 is a cell-permeable, potent and selective JNK3 (c-Jun N-terminal kinase 3) inhibitor.
SR-3576 is a small molecule inhibitor belonging to aminopyrazole class that selectively inhibits JNK3 with >2800 fold selectively over p38.1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Ted Kamenecka et al.
The Journal of biological chemistry, 284(19), 12853-12861 (2009-03-06)
c-Jun N-terminal kinase 3alpha1 (JNK3alpha1) is a mitogen-activated protein kinase family member expressed primarily in the brain that phosphorylates protein transcription factors, including c-Jun and activating transcription factor-2 (ATF-2) upon activation by a variety of stress-based stimuli. In this study
Sara Barreto et al.
Acta biomaterialia, 53, 59-69 (2017-02-22)
In order to identify the mechanisms by which skeletal maturity alters the mechanosensitivity of mesenchymal stromal cells (MSCs) and, the implications for osteogenesis and angiogenesis during bone formation, we compared the response of MSCs derived from children and skeletally-mature healthy
Mei-Chou Lai et al.
Nutrients, 15(3) (2023-02-12)
Degenerative diseases of the brain include Parkinson's disease (PD), which is associated with moveable signs and is still incurable. Hispidin belongs to polyphenol and originates primarily from the medicinal fungi Inonotus and Phellinus, with distinct biological effects. In the study
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