生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous glycerol solution
用途
sufficient for 10 blots
种属反应性
mouse, human, rat
技术
dot blot: suitable
western blot: 1:1,000 using rat brain lysate
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... SYT1(6857)
mouse ... Syt1(20979)
rat ... Syt1(25716)
一般描述
SYT1 (synaptotagmin-1) or phospho-Synaptotagmin is a calcium binding synaptic vesicle protein, that is located on chromosome 12q21. It is usually present in nerve cells.
免疫原
synthetic phosphopeptide corresponding to amino acids residues surrounding the serine 309 of synaptotagmin (Syt).
生化/生理作用
Synaptotagmin-1 (SYT1) is an essential factor for exocytosis, endocytosis and vesicular Ca2+/H+ antiport activity.
外形
Solution in 10 mM HEPES, pH 7.5, 150 mM NaCl with 100 μg/mL BSA and 50% glycerol.
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Transancestral mapping and genetic load in systemic lupus erythematosus
Langefeld CD, et al.
Nature Communications, 8 (2017)
Salvatore Santamaria et al.
mAbs, 9(4), 595-602 (2017-03-18)
The potent aggrecanase ADAMTS-5 is constitutively secreted by chondrocytes, but it is rapidly endocytosed in normal cartilage via the cell surface endocytic receptor LRP1. Therefore it is difficult to detect the total ADAMTS-5 activity produced. In this study, we isolated
Differential Membrane Binding Mechanics of Synaptotagmin Isoforms Observed in Atomic Detail
Vermaas JV and Tajkhorshid E
Biochemistry, 56(1), 281-293 (2017)
Identification of a human synaptotagmin-1 mutation that perturbs synaptic vesicle cycling
Baker K, et al.
The Journal of Clinical Investigation, 125(4), 1670-1678 (2015)
Anna-Carina Weiss et al.
Development (Cambridge, England), 141(17), 3420-3430 (2014-08-21)
The vesico-ureteric junction (VUJ) forms through a complex developmental program that connects the primordium of the upper urinary tract [the nephric duct (ND)] with that of the lower urinary tract (the cloaca). The signals that orchestrate the various tissue interactions
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