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物種活性
human
包裝
kit of 96 wells (12 strips x 8 wells)
技術
ELISA: suitable
輸入
sample type cell culture supernatant(s)
sample type plasma
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 10 pg/ml
檢測方法
colorimetric
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... NELL1(4745)
一般說明
The NELL-1 (neural EGFL like 1) gene encodes an extracellular glycoprotein and is mapped to human chromosome 11p15. Nell-1 is a 810 amino acids protein containing thrombospondin-1 module at its N-terminus and includes other motifs : five von Willebrand factor C domains and six epidermal growth factor (EGF)-like domains.
This ELISA antibody pair detects human NELL-1. Other species are not determined.
應用
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
生化／生理作用
NELL-1 (neural EGFL like 1) is associated with the risk of Rhabdomyosarcomas and the gene is identified to be hypomethylated. The protein encoded influences osteogenic related processes and thus loss of the NELL-1 gene function leads to abnormality in bone and cartilage. NELL-1 is considered as a essential factor in skeletal development as it controls the action of runt-related transcription factor 2. Lack of Nell-1 protein decreases the expression of gene encoding cartilage proteins such as collagens, tenascins, matrilins, and chondroadherin. It serves as an important growth factor in promoting regeneration of articular cartilage. NELL-1 is a tumor suppressor gene and hypermethylation of its promoter region indicates poor prognosis of the disease in esophageal adenocarcinoma.
其他說明
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
訊號詞
Warning
危險聲明
防範說明
危險分類
Met. Corr. 1
儲存類別代碼
8A - Combustible corrosive hazardous materials
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Accelerated chondrogenic differentiation of human perivascular stem cells with NELL-1.
Li C S, et al.
Tissue Engineering: Part A, 22(3-4), 272-285 (2016)
NELL1, whose high expression correlates with negative outcomes, has different methylation patterns in alveolar and embryonal rhabdomyosarcoma.
Tombolan L, et al.
Oncotarget, 8(20), 33086-33086 (2017)
Novel Wnt regulator NEL-like molecule-1 antagonizes adipogenesis and augments osteogenesis induced by bone morphogenetic protein 2.
Shen J, et al.
The American Journal of Pathology, 186(2), 419-434 (2016)
MALDI-TOF mass array analysis of Nell-1 promoter methylation patterns in human gastric cancer.
Gao C, et al.
BioMed Research International, 2015 (2015)
Ritsuko Nakamura et al.
Cancer science, 106(5), 656-664 (2015-03-03)
Neural epidermal growth factor-like like (NELL) 1 and 2 constitute a family of multimeric and multimodular extracellular glycoproteins. Although the osteogenic effects of NELL1 and functions of NELL2 in neural development have been reported, their expression and functions in cancer
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