RAB1127

小鼠PAI-1 ELISA试剂盒

for cell culture supernatants, plasma, and serum samples

• UNSPSC代码: 41116158
• NACRES: NA.32

属性

• 种属反应性: mouse, human
• 技术: ELISA: suitable
• assay range: inter-assay cv: <12%; intra-assay cv: <10%; sensitivity: 80 pg/ml
• 运输: wet ice
• 储存温度: −20°C

说明

一般描述

The PAI-1 (plasminogen activator inhibitor) gene is localized to human chromosome 7q22.1. Active form of PAI-1 is expressed in the blood and tissues. Platelets harbor both the active and latent forms of PAI-1.

This ELISA antibody pair detects mouse and human PAI-1.

应用

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

生化/生理作用

PAI-1 (plasminogen activator inhibitor) produced by platelets takes part in stabilizing blood clotting mechanism. PAI-1 prevents plasminogen activation during fibrinolysis. This might lead to the risk of cardiovascular disease. Elevated levels of PAI-1 has been observed in type 2 diabetes mellitus and serves the reason for reduced insulin sensitivity. PAI-1 stimulates the process of cellular senescence. PAI-1 regulation occurs through p53 dependent TGF-β (transforming growth factor-β) signalling. Studies also also predict that stress and depression might influence PAI-1 expression.

其他说明

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

安全信息

• 象形图: GHS05
• 警示用语：: Warning
• 危险声明: H290
• 预防措施声明: P234 - P390
• 危险分类: Met. Corr. 1
• 储存分类代码: 8A - Combustible corrosive hazardous materials
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable