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物種活性
human
包裝
kit of 96 wells (12 strips x 8 wells)
技術
ELISA: suitable
capture ELISA: suitable
輸入
sample type cell culture supernatant(s)
sample type urine
sample type plasma
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 6 pg/mL
standard curve range: 8.23-6000 pg/mL
檢測方法
colorimetric
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... MMP13(4322)
一般說明
The Human MMP-13 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human MMP-13 in serum, plasma, cell culture supernatants and urine.
免疫原
Recombinant Human MMP13
應用
请参考Protocol了解详情。
生化／生理作用
MMP13 (matrix metalloproteinase 13) functions against different types of ECM (extracellular matrix) components. It gets activated by and activates multiple MMPs and hence, has a central role in the MMP cascade. This protein is frequently expressed in colorectal cancer (CRC) and this expression is linked with poor survival in CRC. MMP13 expression is absent in normal breast tissue, but is present in breast carcinoma suggesting its role in tumorigenesis. The expression of this protein can serve as a marker for tumor invasiveness, as its expression is induced during metastasis of multiple types of cancers, including squamous cell carcinomas of the head and neck and this expression is usually linked to poor prognosis. Missense mutation in this gene results in the autosomal dominant disorder called Missouri type of human spondyloepimetaphyseal dysplasia (SEMDMO), which is characterized by abnormal growth and modeling of vertebrae and long bones.
其他說明
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
訊號詞
Warning
危險聲明
防範說明
危險分類
Met. Corr. 1
儲存類別代碼
8B - Non-combustible corrosive hazardous materials
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Matrix metalloproteinase 13-containing exosomes promote nasopharyngeal carcinoma metastasis.
You Y
Cancer Science null
Yoko Sawada et al.
Experimental and therapeutic medicine, 14(5), 4561-4571 (2017-11-08)
The aim of the present study was to assess the efficacy and safety of the oral administration of
Wen Li et al.
Biomolecules, 9(3) (2019-03-21)
Matrix metalloproteinases (MMPs) are capable of degrading and modifying most components of the extracellular matrix (ECM) and the basal membrane (BM), and play crucial roles in cancer invasion and metastasis. MMP gene expressions were regulated primarily at the transcriptional level
Chuanhao Jiang et al.
Experimental cell research, 361(1), 46-55 (2017-10-07)
Syphilis is a chronic disease caused by Treponema pallidum and the pathogenesis is still unclear. T. pallidum infection induced inflammatory responses are involved in the immunopathological damage in skin and other tissues. Flagellin, the monomeric subunit of bacterial flagella, is
Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas.
Freije JM
The Journal of Biological Chemistry null
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