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Merck
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R140

Sigma-Aldrich

Ro 04-6790 二盐酸盐

solid

别名:

4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]benzenesulfonamide dihydrobromide

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About This Item

经验公式（希尔记法）:
C12H16N6O2S · 2HCl
CAS号:
202466-68-0
分子量:
381.28
MDL编号:
MFCD11045584
UNSPSC代码:
12352202
PubChem化学物质编号:
24278570
NACRES:
NA.77

表单

solid

颜色

white

溶解性

DMSO: >10 mg/mL
H2O: >10 mg/mL

创始人

Roche

SMILES字符串

Cl.Cl.CNc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(NC)n1

InChI

1S/C12H16N6O2S.2ClH/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9;;/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18);2*1H

InChI key

QOAXXMSJHQHSFV-UHFFFAOYSA-N

基因信息

human ... HTR6(3362)

生化/生理作用

Selective 5-HT6 serotonin receptor antagonist.

特点和优势

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

注意

Photosensitive

法律信息

Manufactured and sold under license from Hoffman LaRoche.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
118H4740
070K4605
041K4616

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A J Sleight et al.
British journal of pharmacology, 124(3), 556-562 (1998-07-01)
1. This study describes the in vitro characterization of two potent and selective 5-HT6 receptor antagonists at the rat and human recombinant 5-HT6 receptor. 2. In binding assays with [3H]-LSD, 4-amino-N-(2,6 bis-methylamino-pyrimidin-4-yl)-benzene sulphonamide (Ro 04-6790) and 4-amino-N-(2,6 bis-methylamino-pyridin-4-yl)-benzene sulphonamide (Ro
Bofan Yu et al.
Cell cycle (Georgetown, Tex.), 18(20), 2641-2650 (2019-08-15)
Noncoding RNAs play important roles in the progression of malignant tumors, including triple negative breast cancer (TNBC). Accumulating evidence supported the involvement of the oncogenic MUC1 in tumor metastasis. Our study aimed to explore the roles of miR-140-5p and MUC1
J C Bentley et al.
British journal of pharmacology, 126(7), 1537-1542 (1999-05-14)
1. The present study examined the effects of the selective 5-HT6 receptor antagonist 4-amino-N-(2, 6 bis-methylamino-pyrimidin-4-yl)-benzene sulphonamide (Ro 04-6790) on locomotor activity and unconditioned behaviour in male Sprague Dawley rats (230-300 g). 2. In non-quantified behavioural observations, animals treated with

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