Q4972

QS11 hydrate

≥98% (HPLC), powder

• 别名: (2S)-2-[2-(Indan-5-yloxy)-9-(1,1′-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol hydrate
• 经验公式（希尔记法）: C₃₆H₃₃N₅O₂ · xH₂O
• CAS号: 944328-88-5
• 分子量: 567.68 (anhydrous basis)
• MDL编号: MFCD12912439
• UNSPSC代码: 12352203

属性

• 方案: ≥98% (HPLC)
• 表单: powder
• 颜色: white
• 溶解性: DMSO: >10 mg/mL
• 储存温度: 2-8°C
• SMILES字符串: O.OC[C@H](Cc1ccccc1)Nc2nc(Oc3ccc4CCCc4c3)nc5n(Cc6ccc(cc6)-c7ccccc7)cnc25

说明

生化/生理作用

QS11 is an inhibitor of GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1), as well as a synergizer of the Wnt/β-catenin signaling pathway.

QS11 is an inhibitor of GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1), as well as a synergizer of the Wnt/β-catenin signaling pathway. The Wnt/β-catenin signaling pathway regulates cell morphology, motility, proliferation, and differentiation during development. The GTPase activating protein of ADP-ribosylation factors (ARFGAPs) regulates the small GTPase ADP-ribosylation factors (ARFs) that mediate a number of biological processes, including vesicle trafficking and cytoskeleton reorganization. QS-11 binds and inhibits GTPase activating protein of ADP-ribosylation factor1 (ARFGAP1). Inhibition of ARFGAPs increases the level of activated ARF and subsequent β-catenin translocation leading to pathway activation.

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable
• 个人防护装备: Eyeshields, Gloves, type N95 (US)