推荐产品
product name
阿西替尼, ≥98% (HPLC)
化驗
≥98% (HPLC)
形狀
powder
顏色
white to tan
溶解度
DMSO: ≥8 mg/mL
儲存溫度
room temp
SMILES 字串
CNC(=O)c1ccccc1Sc2ccc3c(\C=C\c4ccccn4)n[nH]c3c2
InChI
1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+
InChI 密鑰
RITAVMQDGBJQJZ-FMIVXFBMSA-N
基因資訊
human ... FLT1(2321) , FLT4(2324) , KDR(3791)
應用
阿昔替尼已被用作血管内皮生长因子 (VEGF) 受体酪氨酸激酶抑制剂 (TKI) ，以研究其对肾癌细胞体外增殖的影响。此外，在调理水 (CW) 中维持的脱氯胚胎中，它还用于抑制肠系膜上动脉 (AMA) 血管生成。
生化／生理作用
阿昔替尼 (AG-013736) 是一种口服强效（皮摩）选择性酪氨酸激酶抑制剂，可阻断VEGF受体 1、2 和 3。该药物可通过内皮型一氧化氮合成酶、Akt和细胞外信号调节激酶，阻断VEGF介导的内皮细胞存活、血管形成及下游信号传导。
特點和優勢
这种化合物是激酶磷酸酶生物学研究的特色产品。点击此处发现更多特色激酶磷酸酶生物产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
法律資訊
根据辉瑞公司的协议出售，用于研究目的。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral - Aquatic Acute 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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