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主要文件

PRS2125

Sigma-Aldrich

Anti-MYD88 (ab1) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

别名:

Anti-Myeloid differentiation primary response gene (88)

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About This Item

MDL编号:
UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

predicted mol wt 35 kDa

种属反应性

human

技术

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt登记号

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... MYD88(4615)

一般描述

Myeloid differentiation primary response 88 (MYD88) is a cytosolic soluble adaptor protein. It possesses a toll-interleukin 1 receptor domain and a death domain. The gene encoding this protein is localized on human chromosome 3p22.2.

免疫原

a peptide corresponding to amino acids 233-248 of human MyD88, which differ from mouse by two amino acids.

生化/生理作用

Myeloid differentiation primary response 88 (MYD88) activates innate immune response to Mycobacterium tuberculosis. It is an activator of nuclear factor κ B (NF-κB).The protein mediates the signaling pathways of toll-like and interleukin-1 receptors. Mutation in the gene encoding MYD88 is associated with diffuse large B-cell lymphoma.

联系

The action of this antibody can be blocked using blocking peptide SBP2125.

外形

Solution in phosphate buffered saline containing 0.02% sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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说明
价格

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Regional copy number?independent deregulation of transcription in cancer
Nicolas Stransky
Nature Genetics, 38(12) (2006)
Conformational dynamics of cancer-associated MyD88-TIR domain mutant L252P (L265P) allosterically tilts the landscape toward homo-dimerization.
Zhan C
Protein engineering, design & selection : PEDS, 29(9), 347-354 (2016)

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