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Merck

PLA0083

Sigma-Aldrich

Rabbit anti-FUS Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

别名:

75 kDa DNA-pairing protein, ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS, amyotrophic lateral sclerosis 6, derived from t(12;16) malignant liposarcoma, fus-like protein, fused in sarcoma, fusion, fusion (involved in t(12;16) in malignant liposarcoma), fusion gene in myxoid liposarcoma, heterogeneous nuclear ribonucleoprotein P2, hnRNP-P2, oncogene FUS, oncogene TLS, translocated in liposarcoma, translocated in liposarcoma protein

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

抗體表格

affinity purified immunoglobulin

抗體產品種類

primary antibodies

等級

Powered by Bethyl Laboratories, Inc.

物種活性

mouse, human

技術

immunohistochemistry: 1:1,000-1:5,000
immunoprecipitation (IP): 2-10 μg/mg
western blot: 1:2,000-1:10,000

登錄號

P35637

UniProt登錄號

運輸包裝

wet ice

儲存溫度

2-8°C

目標翻譯後修改

unmodified

基因資訊

rabbit ... FUS(2521)

免疫原

The epitope recognized by PLA0083 maps to a region between residues 400 and 450 of human fusion (involved in t(12;16) in malignant liposarcoma) using the numbering given in SwissProt entry P35637 (GeneID 2521).

外觀

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

其他說明

FUS has been identified as a frequent translocation fusion partner of various transcription factors. FUS fusion genes have been shown to be associated with multiple tumor types which include liposarcoma, leukemia, histocytoma, and sarcoma. FUS is a multifunctional RNA-binding protein that associates with the nuclear matrix and Cajal bodies and appears to play a role in splicesome assembly, pre-mRNA splicing, DNA repair, transcriptional regulation and homologous recombination.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Tomoyasu Matsubara et al.
Neuropathology : official journal of the Japanese Society of Neuropathology, 39(1), 47-53 (2018-12-05)
Amyotrophic lateral sclerosis (ALS) primarily affects upper and lower motor neurons. Phosphorylated trans-activation response DNA-binding protein of 43 kDa (TDP-43) inclusion bodies are reportedly a pathological hallmark of sporadic ALS. Here, we present an atypical case of sporadic ALS that

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