P8953

Platelet-Derived Growth Factor from porcine platelets

PDGF, lyophilized powder, suitable for cell culture

• 别名: PDGF
• MDL號碼: MFCD00166903
• 分類程式碼代碼: 12352202
• NACRES: NA.77

属性

• 生物源: Porcine
• 品質等級: 200
• 化驗: ≥97% (SDS-PAGE and N-terminal analysis)
• 形狀: lyophilized powder
• 效力: 39.00 ng/mL EC₅₀
• 品質: endotoxin tested
• 分子量: glycoprotein 38 kDa
• 包裝: pkg of 5 μg
• 儲存條件: avoid repeated freeze/thaw cycles
• 技術: cell culture | mammalian: suitable
• 雜質: ≤1 EU/μg
• 顏色: white
• UniProt登錄號: P20034
• 儲存溫度: −20°C
• 基因資訊: pig ... PDGFB(100626465)

说明

應用

PDGF elicits multifunctional actions with a variety of cells, including mitogenesis of mesoderm-derived cells, increased extracellular matrix synthesis, and chemotaxis and activation of neutrophils, monocytes and fibroblasts.

生化／生理作用

The principal mitogen found in mammalian serum, released from platelets during clot formation. Elicits mitogenesis of mesoderm-derived cells, increased extracellular matrix synthesis, and chemotaxis and activation of neutrophils, monocytes and fibroblasts. Mitogenic for dermal and tendon fibroblasts, vascular smooth muscle cells, glial cells and chondrocytes. Appears to interact with transforming growth factor-β1 in accelerating wound healing. However, platelet-derived growth factor (PDGF) may also be pathogenic in arteriosclerosis and neoplasia.

外觀

Lyophilized from a 0.2 μm filtered solution in 40% acetonitrile and 0.1% trifluoroacetic acid, pH 2.0.

分析報告

The mitogenic activity is tested in culture using Swiss 3T3 cells or NR6-3T3 fibroblasts.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)