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About This Item
经验公式（希尔记法）:
C21H18O5
CAS号:
分子量:
350.36
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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化驗
≥98% (HPLC)
形狀
solid
儲存條件
protect from light
顏色
white
溶解度
DMSO: 9 mg/mL
儲存溫度
2-8°C
SMILES 字串
O=C1Oc2cc3occc3c(OCCCCOc4ccccc4)c2C=C1
InChI
1S/C21H18O5/c22-20-9-8-16-19(26-20)14-18-17(10-13-24-18)21(16)25-12-5-4-11-23-15-6-2-1-3-7-15/h1-3,6-10,13-14H,4-5,11-12H2
InChI 密鑰
KINMYBBFQRSVLL-UHFFFAOYSA-N
生化／生理作用
5-（4-苯氧基丁氧基）补骨脂素（PAP-1） 源自天然化合物 5-甲氧基补骨脂素。PAP-1 对 Kv1.3（电压门控钾通道）的选择性高于其他 Kv1 家族成员。Kv1.3 主要存在于激活的效应记忆 T 细胞的细胞膜上。Kv1.3 的抑制导致膜去极化。在大鼠模型中，已知 PAP-1 可以延缓糖尿病的发作。它可能用于治疗银屑病和效应记忆 T 细胞介导的自身免疫性疾病。PAP-1 的口服、腹膜内和局部给药可预防恶唑酮诱导的过敏性接触性皮炎。
Kv1.3 的选择性抑制剂，电压门控 K+ 通道。PAP-1（EC50=2 nM） 有效抑制人 T 效应记忆细胞增殖和延迟超敏反应。口服或腹腔内有效。5-（4-苯氧基丁氧基）补骨脂素对 Kv1.3 的选择性比 Kv1.5 高 23 倍，比其他 Kv1 家族通道的选择性高 33-125 倍。
訊號詞
Danger
危險聲明
危險分類
Resp. Sens. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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