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重组
expressed in baculovirus infected Sf9 cells
质量水平
产品线
PRECISIO® Kinase
方案
≥70% (SDS-PAGE)
表单
buffered aqueous glycerol solution
比活
14-20 nmol/min·mg
分子量
~70 kDa
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... PLK1(5347)
一般描述
PLK1 (polo like kinase 1) gene is mapped to human chromosome 16p12.2. It codes for the protein serine/threonine kinase.
生化/生理作用
PLK1 (polo like kinase 1) is predominantly involved in mitosis. It mediates the phosphorylation of cyclin B1/CDK1 (cyclin dependent kinase 1) complex, and activation of the anaphase promoting complex. PLK1 has anti-apoptotic function. Upregulation of gene is observed in different types of cancer, such as colorectal cancer and is regarded as an oncogene. PLK1 is involved in checkpoint recovery and adaptation following DNA damage.
外形
Supplied in 50 mM Sodium Phosphate, pH 7.0, with 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, and 25% glycerol.
法律信息
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险声明
危险分类
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Polo-like kinase 1 expression is suppressed by CCAAT/enhancer-binding protein a to mediate colon carcinoma cell differentiation and apoptosis.
Dasgupta N
Biochimica et Biophysica Acta (2017)
Expression of the microtubule-associated protein MAP9/ASAP and its partners AURKA and PLK1 in colorectal and breast cancers.
Rouquier S
Disease Markers (2014)
E A Nigg et al.
Experimental cell research, 229(2), 174-180 (1996-12-15)
During mitosis, the vertebrate cell nucleus undergoes profound changes in architecture. At the onset of mitosis, the nuclear envelope breaks down, the nuclear lamina is depolymerized, and interphase chromatin is condensed to chromosomes. Concomitantly, cytoplasmic microtubules are reorganized into a
Wei Dai et al.
Progress in cell cycle research, 5, 327-334 (2003-11-05)
Studies from eukaryotic model systems, ranging from yeast to human, indicate that Polo and Polo-like kinases (Plks) are essential for the activity of the microtubule organization center. Polo/Plks localize to centrosomes or spindle pole bodies and undergo dramatic subcellular relocation
Polo-like Kinase 1 as a potential therapeutic target in Diffuse Intrinsic Pontine Glioma.
Amani V
BMC Cancer (2016)
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