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Merck
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文件

O9126

Sigma-Aldrich

Oxotremorine sesquifumarate salt

≥98% (HPLC), solid

别名:

1-(4-[1-Pyrrolidinyl]-2-butynyl)-2-pyrrolidinone, 1-(4-[1-Pyrrolidinyl]2-butynyl)-2-pyrrolidinone

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About This Item

经验公式（希尔记法）:
C12H18N2O · 1.5C4H4O4 · xH2O
CAS号:
17360-35-9
分子量:
380.39 (anhydrous basis)
EC號碼:
241-388-3
MDL號碼:
MFCD00013163
分類程式碼代碼:
12352200
PubChem物質ID:
24278614
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

solid

mp

102-105 °C (lit.)

溶解度

H2O: >10 mg/mL

儲存溫度

2-8°C

SMILES 字串

[H]\C(=C(\[H])C(O)=O)C(O)=O.[H]\C(=C(\[H])C(O)=O)C(O)=O.[H]\C(=C(\[H])C(O)=O)C(O)=O.O=C1CCCN1CC#CCN2CCCC2.O=C3CCCN3CC#CCN4CCCC4

InChI

1S/2C12H18N2O.3C4H4O4/c2*15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13;3*5-3(6)1-2-4(7)8/h2*1-2,5-11H2;3*1-2H,(H,5,6)(H,7,8)/b;;3*2-1+

InChI 密鑰

WLYYOFJEBGHKEC-VQYXCCSOSA-N

基因資訊

human ... CHRM2(1129)

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生化／生理作用

Oxotremorine sesquifumarate salt is a muscarinic acetylcholine receptor agonist with preference for the M2 receptor.

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H300 + H310 + H330

危險分類

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 3

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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I B Introini-Collison et al.
Behavioral and neural biology, 57(3), 248-255 (1992-05-01)
Post-training administration of the centrally acting muscarinic agonist oxotremorine (50.0 microgram/kg, ip) facilitated 48-hr retention, in mice, of a one-trial step-through inhibitory avoidance response. Oxotremorine-induced memory facilitation was not prevented by the simultaneous post-training administration of the central beta-adrenoceptor antagonist
P G Gunasekar et al.
Neuroscience research, 49(1), 13-18 (2004-04-22)
Cyanide is generated in neurons and this report examines the two different receptors which mediate cyanide formation in neuronal tissue. An opiate receptor blocked by naloxone increases cyanide production both in rat brain and in rat pheochromocytoma (PC12) cells. A
J D Brioni et al.
Behavioral and neural biology, 50(3), 251-254 (1988-11-01)
The pre-test administration of beta-endorphin (0.05 microgram/mouse), oxotremorine sesquifumarate (5.0 micrograms/mouse), or beta-endorphin plus oxotremorine enhanced retention test performance of a conditioned emotional response in mice. The effects were blocked by scopolamine. Scopolamine had no effect of its own. The
T Reinheimer et al.
American journal of respiratory and critical care medicine, 156(2 Pt 1), 389-395 (1997-08-01)
Human bronchi were incubated in organ baths to measure histamine release. The calcium ionophore A23187 (10 mumol/L; 1 min) stimulated histamine release by 148 +/- 28% (n = 11) above the prestimulation level but was ineffective in epithelium-denuded bronchi. Neither
I Izquierdo et al.
Pharmacology, biochemistry, and behavior, 33(3), 545-548 (1989-07-01)
CD-1 mice were trained in a classically conditioned emotional response paradigm and tested 24 hr later. Exposure to an open field 0 or 1, but not 3 hr after training retroactively interfered with retention of the conditioned emotional response. The
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