O8014

Org 27569

≥98% (HPLC)

• 别名: 5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide
• 经验公式（希尔记法）: C₂₄H₂₈ClN₃O
• CAS号: 868273-06-7
• 分子量: 409.95
• EC號碼: 278-169-7
• MDL號碼: MFCD11045300
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329818922

属性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white
• 溶解度: H₂O: <2 mg/mL; DMSO: >5 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: CCc1c([nH]c2ccc(Cl)cc12)C(=O)NCCc3ccc(cc3)N4CCCCC4
• InChI: 1S/C24H28ClN3O/c1-2-20-21-16-18(25)8-11-22(21)27-23(20)24(29)26-13-12-17-6-9-19(10-7-17)28-14-4-3-5-15-28/h6-11,16,27H,2-5,12-15H2,1H3,(H,26,29)
• InChI 密鑰: AHFZDNYNXFMRFQ-UHFFFAOYSA-N

说明

生化／生理作用

Org 27569 is an allosteric modulator of CB₁ cannabinoid receptor. It significantly increases the binding of CB₁ receptor agonist [³H]-CP 55,940 (pK_B = 5.67) and causes a significant decrease in specific binding of CB₁ receptor inverse agonist SR141716A (Rimonabant; pK_B = 5.95); in the reporter gene assay behaves as insurmountable CP 55,940 antagonist; pK_B = 7.57 at CB₁ receptors in mouse vas deferens

安全信息

• 儲存類別代碼: 13 - Non Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)