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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~230 kDa
antigen ~80 kDa
物種活性
mouse, human, rat
濃度
~1 mg/mL
技術
immunohistochemistry: 1:100-1:200
western blot: 1:500-1:1,000
UniProt登錄號
應用
research pathology
運輸包裝
dry ice
儲存溫度
−20°C
基因資訊
human ... NOTCH4(4855)
mouse ... Notch4(18132)
rat ... Notch4(406162)
一般說明
NOTCH homolog-4 (NOTCH4) is expressed in breast cancer.
免疫原
synthetic peptide corresponding to residues 1506-1524 of human NOTCH4. This sequence is 89% identical in mouse and rat.
生化／生理作用
NOTCH homolog-4 (NOTCH4) has an intracellular domain which detaches from the protein on activation. This domain then translocates to the nucleus and modulates transcription of genes. NOTCH4 also activates various pathways and contributes to carcinogenesis. Mutations in the gene encoding the protein may be linked to schizophrenia.
外觀
solution in phosphate buffered saline, containing 0.02% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Genetic variability testing of neurodevelopmental genes in schizophrenic patients.
Terzic T
Journal of Molecular Neuroscience, 56(1), 205-211 (2015)
NOTCH4 is a potential therapeutic target for triple-negative breast cancer.
Nagamatsu I
Anticancer Research, 34(1), 69-80 (2014)
Cuijuan Qian et al.
Molecular and cellular biochemistry, 401(1-2), 165-174 (2014-12-17)
Gastric cancer (GC) is one of the most common cancers and lethal malignancies in the world. Discovering novel biomarkers that correlate with GC may provide opportunities to reduce the severity of GC. As one of Notch receptor family members in
AKT and 14-3-3 regulate Notch4 nuclear localization.
Ramakrishnan G
Scientific Reports, 5, 8782-8782 (2015)
Fernanda Silva et al.
Oncology letters, 12(4), 2686-2691 (2016-10-05)
Epithelial ovarian cancer is the most lethal gynecologic malignancy, despite advances in treatment. The most common histological type, high-grade ovarian serous carcinoma (OSC) is usually diagnosed at an advanced stage, and although these types of tumors frequently respond to surgery
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