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Merck
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主要文件

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N179

Sigma-Aldrich

NS 102

solid

别名:

6,7,8,9-Tetrahydro-5-nitro-1H-benz[g]indole-2,3-dione 3-oxime

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About This Item

经验公式（希尔记法）:
C12H11N3O4
CAS号:
136623-01-3
分子量:
261.23
分類程式碼代碼:
12352200
PubChem物質ID:
24897529
NACRES:
NA.32

形狀

solid

顏色

yellow

溶解度

DMSO: >3 mg/mL
H2O: insoluble
methanol: insoluble

SMILES 字串

O\N=C1/C(=O)Nc2c3CCCCc3c(cc12)[N+]([O-])=O

InChI

1S/C12H11N3O4/c16-12-11(14-17)8-5-9(15(18)19)6-3-1-2-4-7(6)10(8)13-12/h5,17H,1-4H2,(H,13,14,16)

InChI 密鑰

SCDBMLHUXJBJSS-UHFFFAOYSA-N

基因資訊

human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRIN3A(116443) , GRIN3B(116444) , GRINA(2907)
mouse ... GRIN1(14810) , GRIN2A(14811) , GRIN2B(14812) , GRIN2C(14813) , GRIN2D(14814) , GRIN3A(242443) , GRIN3B(170483) , GRINA(66168)
rat ... GRIN1(24408) , GRIN2A(24409) , GRIN2B(24410) , GRIN2C(24411) , GRIN2D(24412) , GRIN3A(191573) , GRIN3B(170796) , GRINA(266668)

生化／生理作用

Competitive glutamate receptor antagonist with high selectivity for the low-affinity [3H] kainate binding site.

法律資訊

Sold under exclusive license from NeuroSearch A/S.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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R A Tasker et al.
Canadian journal of physiology and pharmacology, 74(9), 1047-1054 (1996-09-01)
Our objective was to characterize the neurotoxic actions of systemically administered domoic acid on different excitatory amino acid receptors, and to compare the receptor selectivity of domoate with the related compound kainic acid. Groups of mice were injected with various
T H Johansen et al.
European journal of pharmacology, 246(3), 195-204 (1993-08-15)
5-Nitro-6,7,8,9-tetrahydrobenzo[G]indole-2,3-dione-3-oxime (NS-102), a new competitive glutamate receptor antagonist displaced binding to non-N-methyl-D-aspartate (non-NMDA) binding sites with no activity at the NMDA and strychnine-insensitive glycine binding sites. Under experimental conditions in which both high- and low-affinity sites were labelled, NS-102 only
H Kamiya et al.
The Journal of physiology, 509 ( Pt 3), 833-845 (1998-05-23)
1. The effect of a low concentration (1 microM) of kainate (kainic acid; KA) on presynaptic calcium (Ca2+) influx at the Schaffer collateral-commissural (SCC) synapse was examined in rat hippocampal slices. 2. Following selective loading of the presynaptic terminals with
Toshiaki Minami et al.
British journal of pharmacology, 142(4), 679-688 (2004-05-26)
1. Ingestion of a poisonous mushroom Clitocybe acromelalga is known to cause severe tactile pain (allodynia) in the extremities for a month and acromelic acid (ACRO), a kainate analogue isolated from the mushroom, produces selective damage of interneurons of the
Hubert Monnerie et al.
Journal of neuroscience research, 83(6), 944-956 (2006-02-25)
Glutamate is an important regulator of dendrite development that may inhibit, (during ischemic injury), or facilitate (during early development) dendrite growth. Previous studies have reported mainly on the N-methyl-D-aspartate (NMDA) receptor-mediated dendrite growth-promoting effect of glutamate. In this study, we
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