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Merck

MAK192

Sigma-Aldrich

胆固醇外流检测试剂盒

Sufficient for 100 Fluorometric tests

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About This Item

UNSPSC代码:
12161503

应用

cosmetics
food and beverages
pharmaceutical

检测方法

fluorometric

相关疾病

cardiovascular diseases

储存温度

−20°C

一般描述

胆固醇逆向转运 (RCT) 是通过转运至肝脏及其粪便排泄,降低外周脂质负荷的机制。RCT 的第一步是动脉粥样硬化斑块中巨噬细胞源性泡沫细胞的胆固醇流出。胆固醇外流对于维持动脉壁净胆固醇平衡和减少由富含脂质的巨噬细胞触发的促炎症反应至关重要。

应用

胆固醇外流测定试剂盒已用于胆固醇外流测定。

特点和优势

兼容高通量操作系统。

适用性

适用于细胞内胆固醇外流的测定。

原理

胆固醇外排检测试剂盒是一种高通量筛选分析试剂盒,通过荧光标记的胆固醇检测细胞中的胆固醇外排(λEx = 482 nm/ λEm = 515 nm)。适用于血清、分离或重组脂蛋白样本。也可根据胆固醇外排作用筛选小分子,因此可作为有价值的药物发现工具。

仅试剂盒组分

产品编号
说明

  • Labeling Reagent

  • Equilibration Buffer

  • Reagent A

  • Reagent B

  • Cell Lysis Buffer

  • Positive Control

  • Serum Treatment Reagent

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2

储存分类代码

10 - Combustible liquids

闪点(°F)

188.6 °F - closed cup

闪点(°C)

87 °C - closed cup


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Lappeg?rd K T, et al.
Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis, 57(1), 91-96 (2018)
Bariatric surgery improves lipoprotein profile in morbidly obese patients by reducing LDL cholesterol, apoB, and SAA/PON1 ratio, increasing HDL cholesterol, but has no effect on cholesterol efflux capacity.
Kjellmo C A, et al.
Journal of Clinical Lipidology, 12(1), 193-202 (2018)
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Journal of cellular and molecular medicine, 23(8), 5259-5269 (2019-05-24)
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Advanced healthcare materials, 9(14), e2000465-e2000465 (2020-06-17)
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