推荐产品
生物源
rat
品質等級
重組細胞
expressed in NSO cells
化驗
>95% (SDS-PAGE)
形狀
lyophilized powder
分子量
120 kDa by SDS-PAGE
calculated mol wt ~81 kDa
雜質
endotoxin, tested
UniProt登錄號
應用
cell analysis
儲存溫度
−20°C
基因資訊
rat ... Mag(29409)
生化／生理作用
MAG is a type I transmembrane glycoprotein containing five Ig-like domains in its extracellular domain. It is an adhesion molecule belonging to the immunoglobin superfamily. These adhesion molecules bind specifically to cell-surface glycan containing sialic acid residues that define the I-type sialyl lectin subgroup. Thus, they are also called the sialoadhesin family. Sialoadhesins mediate diverse biological processes through recognition of specific sialyted glycans on the cell surface. MAG, a minor component of myelin in the central and peripheral nervous system, has been implicated in the formation and maintenance of myelin. MAG is expressed on myelinating oligodenrocytes and Schwann cells, and preferentially recognize a 2,3-linked sialic acid on O-linked glycans and gangliosides. MAG exists as two isoforms that differ in the sequence and length of the cytoplasmic tail. The large isoform (71 kDa) and small isoform (67 kDa) arise from alternative splicing of mRNAs. Lymphocytes under pathologic conditions, it would normally interact with neuronal cells. It has been shown that MAG promotes axonal growth from neonatal dorsal root ganglion (DRG) neurons and embryonic spinal neurons, but is a potent inhibitor of axonal re-growth from adult DRG and postnatal cerebellar neurons. MAG plays an important role in the interaction between axons and myelin. A soluble form of MAG containing the extracellular domain is released from myelin in large quantities and identified in normal human tissues and in tissues from patients with neurological disorders. This soluble MAG may contribute to the lack of neuronal regeneration after injury.
MAG, a member of the immunoglobin superfamily, is expressed on myelinating oligodendrocytes and Schwann cells. MAG plays an important role in the interacation between axons and myelin.
其他說明
Extracellular domain of rat myelin-associated glycoprotein (MAG) fused to the C-terminal Fc region of human IgG1.
外觀
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
分析報告
Measured by its ability to inhibit neurite outgrowth of cultured embryonic chick dorsal root ganglia neurons.
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
S Kelm et al.
Current biology : CB, 4(11), 965-972 (1994-11-01)
Protein-carbohydrate interactions are believed to be important in many biological processes that involve cell-cell communication. Apart from the selectins, the only well-characterized vertebrate sialic acid-dependent adhesion molecules are CD22 and sialoadhesin; CD22 is a member of the immunoglobulin superfamily that
J L Salzer et al.
The Journal of cell biology, 104(4), 957-965 (1987-04-01)
The myelin associated glycoproteins (MAG) are integral plasma membrane proteins which are found in oligodendrocytes and Schwann cells and are believed to mediate the axonal-glial interactions of myelination. In this paper we demonstrate the existence in central nervous system myelin
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