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M1684

(2S,3S,4S)-2-Methyl-2-(carboxycyclopropyl)glycine

Name: (2S,3S,4S)-2-Methyl-2-(carboxycyclopropyl)glycine
Brand: SIGMA

别名:

(2S,3S,4S)-MCCG

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About This Item

经验公式（希尔记法）:

C₇H₁₁NO₄

CAS号:

157141-16-7

分子量:

173.17

MDL號碼:

MFCD05865221

分類程式碼代碼:

12352200

溶解度

H₂O: >10 mg/mL

儲存溫度

−20°C

SMILES 字串

C[C@](N)([C@H]1C[C@@H]1C(O)=O)C(O)=O

生化／生理作用

Potent antagonist at mGluR2 metabotropic glutamate receptors

分析報告

Stereochemistry confirmed by x-ray crystallography

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Anticonvulsant and glutamate release-inhibiting properties of the highly potent metabotropic glutamate receptor agonist (2S,2'R, 3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV).

P J Attwell et al.

Brain research, 805(1-2), 138-143 (1998-09-12)

The anticonvulsant effects of intracerebral administration of the highly potent group II metabotropic glutamate receptor agonist, DCG-IV, were tested in fully kindled rats following daily electrical stimulation of the basolateral amygdala. The agonist caused a dose-dependent increase in the generalized

Pharmacological characterization of MCCG and MAP4 at the mGluR1b, mGluR2 and mGluR4a human metabotropic glutamate receptor subtypes.

T Knöpfel et al.

Neuropharmacology, 34(8), 1099-1102 (1995-08-01)

The two reported metabotropic glutamate receptor (mGluR) antagonists, alpha-methyl-cyclopropyl glycine (MCCG) and alpha-methyl-aminophosphonobutyrate (MAP4) were tested on the mGluR1b, mGluR2 and mGluR4a subtypes of human mGluRs. Neither MCCG (500 microM) nor MAP4 (500 microM) antagonized the activation of mGluR1b by

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