方案
≥98% (HPLC)
表单
solid
储存条件
desiccated
颜色
white
溶解性
H2O: >20 mg/mL
储存温度
−20°C
SMILES字符串
CS(O)(=O)=O.S=C=Nc1cccc(c1)C2(CCCCC2)N3CCCCC3
InChI
1S/C18H24N2S.CH4O3S/c21-15-19-17-9-7-8-16(14-17)18(10-3-1-4-11-18)20-12-5-2-6-13-20;1-5(2,3)4/h7-9,14H,1-6,10-13H2;1H3,(H,2,3,4)
InChI key
ZASHKPXYYPYQRI-UHFFFAOYSA-N
基因信息
human ... OPRS1(10280)
生化/生理作用
Metaphit methanesulfonate salt is an irreversible, non-competitive antagonist at the phencyclidine site on the NMDA receptor; sigma receptor irreversible, competitive antagonist.
注意
吸湿
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
L S Bluth et al.
European journal of pharmacology, 161(2-3), 273-277 (1989-02-28)
Pretreatment of guinea pig brain membranes with 1-[1-(3-isothiocyanatophenyl)cyclohexyl]piperidine (Metaphit) caused irreversible and differential inhibition of ligand binding to sigma (sigma) receptors. The concentration of Metaphit required to produce 50% inhibition of binding of [3H]1,3-di-o-tolylguanidine ([3H]DTG), [3H](+)-3-(3-hydroxy-phenyl)-N-(1-propyl)piperidine ([3H](+)-3-PPP), and [3H](+)-N-allylnormetazocine ([3H](+)-SKF
I Zimányi et al.
Synapse (New York, N.Y.), 3(3), 239-245 (1989-01-01)
[3H]Mazindol was used to label the dopamine uptake complex in mouse striatum in vitro in the presence and absence of metaphit, an isothiocyanate derivative of phencyclidine. In some experiments, metaphit was present in the incubation fluid throughout the procedure; in
E D French et al.
European journal of pharmacology, 140(3), 267-274 (1987-08-21)
Metaphit, a derivative of phencyclidine (PCP) which irreversibly binds to a population of PCP receptor sites in rat brain, has been considered as a potentially specific PCP antagonist. In whole animal studies, however, metaphit has been shown to have either
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