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Merck

L7140

Sigma-Aldrich

S-乳酰谷胱甘肽

≥90% (TLC)

别名:

SLG

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About This Item

经验公式(希尔记法):
C13H21N3O8S
CAS号:
分子量:
379.39
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.26

品質等級

化驗

≥90% (TLC)

形狀

powder

顏色

white

應用

detection

儲存溫度

−20°C

SMILES 字串

C[C@H](O)C(=O)SC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O

InChI

1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/t6-,7-,8-/m0/s1

InChI 密鑰

VDYDCVUWILIYQF-FXQIFTODSA-N

應用


  • 非靶向代谢组学提供了关于从天然乳清发酵剂中分离的瑞士乳杆菌在甲基乙二醛介导褐变中影响的新见解。: 该研究利用非靶向代谢组学来考察S-乳酰谷胱甘肽在甲基乙二醛介导的褐变反应中的作用,重点介绍了其在食品加工和安全中的影响Galimberti S et al., 2023).

  • 多组学分析揭示了在产蛋鸡中植物乳植杆菌预防LPS诱导的输卵管炎的分子调节网络。: 该研究确认了S-乳酰谷胱甘肽在预防LPS诱导的输卵管炎的分子调节网络中的作用,重点强调了其在鸟类健康和生物技术应用中的重要性(Song D et al., 2023)。

  • 猪肉烤制过程中来源于乙二醛和甲基乙二醛的晚期糖基化终产物的分析。: 该研究考察了来源于乙二醛和甲基乙二醛的晚期糖基化终产物(AGE)的形成,关注了S-乳酰谷胱甘肽在肉类烤制过程中减轻这些反应的作用(Eggen MD et al., 2021)。

生化/生理作用

S-乳酰谷胱甘肽(SLG)用于研究细菌和植物中谷胱甘肽依赖性乙二醛酶系统和 KefGB 钾外排泵。S-乳酰谷胱甘肽也可用于研究癌症中嘧啶从头合成的抑制。

基底

适用于作为乙二醛酶 II 的底物。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

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Nathan F Wenzel et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 9(4), 429-438 (2004-04-07)
Cytosolic glyoxalase 2 (GLX2-2) from Arabidopsis thaliana is a metalloenzyme that has been shown to bind a mixture of Zn, Fe, or Mn when produced in cells grown in rich media. In an effort to prepare metal-enriched samples, GLX2-2 was
L G Edwards et al.
Leukemia research, 20(1), 17-26 (1996-01-01)
The inhibition of human leukaemia 60 cell growth by S-D-lactoylglutathione in vitro is mediated by the inhibtion of de novo pyridimine synthesis. When S-D-lactoylglutathione was added to human leukaemia 60 cells in culture, it was hydrolysed by thiolesterase activity to
T Pourmotabbed et al.
The Journal of biological chemistry, 261(30), 14240-14244 (1986-10-25)
Formaldehyde dehydrogenases isolated from several different biological sources have been reported to catalyze the NAD+-dependent oxidative acylation of glutathione by methylglyoxal to form S-pyruvylglutathione, suggesting the involvement of this enzyme in the metabolism of methylglyoxal. However, formaldehyde dehydrogenase from bovine
A Klimes et al.
Canadian journal of microbiology, 52(9), 816-822 (2006-11-18)
A glyoxalase I gene homologue (VdGLO1) was identified in the vascular wilt fungus Verticillium dahliae by sequence tag analysis of genes expressed during resting structure development. The results of the current study show that the gene encodes a putative 345
Ananda Mustafiz et al.
Methods in molecular biology (Clifton, N.J.), 639, 95-118 (2010-04-14)
Glyoxalase system consists of two enzymes glyoxalase I (Gly I) and glyoxalase II (Gly II). Gly I detoxifies methylglyoxal (MG), a cytotoxic byproduct of glycolysis, to S-lactoylglutathione (SLG) where it uses one molecule of reduced glutathione. Subsequently, SLG is converted

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