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K2768

Sigma-Aldrich

KHS1, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

别名:

GCKR, MAP4K5, MAPKKKK5

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About This Item

UNSPSC代码:
12352204
NACRES:
NA.32

重组

expressed in baculovirus infected Sf9 cells

质量水平

200

产品线

PRECISIO® Kinase

方案

≥70% (SDS-PAGE)

表单

buffered aqueous glycerol solution

比活

76-99 nmol/min·mg

分子量

~135 kDa

UniProt登记号

Q9Y4K4

运输

dry ice

储存温度

−70°C

基因信息

human ... MAP4K5(11183)

生化/生理作用

KHS1 (kinase homologous to SPS1/STE20) is a component of MAP (mitogen activated protein) kinase signaling pathway and is responsible for activation of JUNK (c-Jun N-terminal kinase). Mutation in the promoter region of KHS1 is linked with lower risk of type 2 diabetes. It is also referred to as MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5)

外形

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

法律信息

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Maura Epifanía Matus-Ortega et al.
Biochimica et biophysica acta, 1769(3), 194-203 (2007-03-06)
PNPase is a phosphate-dependent exonuclease of Escherichia coli required for growth in the cold. In this work we explored the effect of specific mutations in its two RNA binding domains KH and S1 on RNA binding, enzymatic activities, autoregulation and
Yanyun Gu et al.
Journal of human genetics, 51(7), 605-610 (2006-05-16)
MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5), an early component of MAP kinase signal cascades was shown to activate Jun kinase in mammalian cells. The association between SNPs of MAP4K5 and type 2 diabetes (T2DM) was investigated due to
C S Shi et al.
Journal of immunology (Baltimore, Md. : 1950), 163(6), 3279-3285 (1999-09-08)
TNF-induced activation of stress activated protein kinases (SAPKs, Jun NH2-terminal kinases) requires TNF receptor associated factor 2 (TRAF2). TRAF2 is a potent activator of a 95-kDa serine/threonine kinase termed germinal center kinase related (GCKR, also referred to as KHS1), which

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