J4500

Anti-c-Jun N-Terminal Kinase antibody produced in rabbit

whole antiserum

• 别名: Anti-JNK1, JNK2
• MDL编号: MFCD00676444
• UNSPSC代码: 12352203
• NACRES: NA.44

属性

• 生物来源: rabbit
• 偶联物: unconjugated
• 抗体形式: whole antiserum
• 抗体产品类型: primary antibodies
• 克隆: polyclonal
• 分子量: antigen, JNK1 46 kDa; antigen, JNK2 55 kDa
• 包含: 15 mM sodium azide
• 种属反应性: rat, human, mouse
• 技术: microarray: suitable; western blot: 1:16,000 using rat brain extract and mouse NIH-3T3 fibroblast extract, respectively; western blot: 1:2,000 using mouse NIH 3T3 fibroblast cell lysate
• UniProt登记号: P45983
• 运输: dry ice
• 储存温度: −20°C
• 靶向翻译后修饰: unmodified
• 基因信息: human ... MAPK8(5599) ; mouse ... Mapk8(26419) ; rat ... Mapk8(116554)

说明

一般描述

Anti-c-Jun N-Terminal Kinase (JNK1, JNK2) is developed in rabbit using a synthetic peptide, corresponding to amino acids of human c-Jun N-terminal kinase 1 (JNK1), coupled to KLH as the immunogen.

JNK (c-Jun N terminal protein kinase, also known as stress activated protein kinase, SAPK1) is a protein that belongs to serine/threonine-protein kinase family. It has a critical role in inhibiting WOX1 (WW domain-containing oxidoreductase) mediated apoptosis. It also mediates starvation-induced BCL2 phosphorylation and activates autophagy. Anti-c-Jun N-terminal kinase antibody can be used in microarray. Rabbit anti-c-Jun N-terminal kinase antibody reacts specifically with JNK1 (46 kD) and JNK2 (55 kD) of cell culture lysates and rat brain tissue extracts. The product has also shown weak cross reactivity for JNK2β (50 kD) isoform in mouse NIH-3T3 fibroblast cell lysate.

免疫原

Synthetic peptide corresponding to amino acids 339-354 of human JNK1 (c-Jun N-terminal kinase 1), conjugated to KLH. The sequence is highly conserved in JNK1, JNK2 α, β, γ (p54 SAPK α, β, γ) and identical in human, rat, and mouse JNK1.

应用

Anti-c-Jun N-Terminal Kinase antibody produced in rabbit has been used in western blotting.

生化/生理作用

Mitogen-activated protein kinases (MAPKs) are serine/threonine kinases which play a central role in mitogenic signaling. The MAPKs function to transduce extracellular signals to intracellular targets, including transcription factors controlling the expression of genes essential to many cellular processes including proliferation, development and differentiation. JNK1 is essential for tumor necrosis factor alpha (TNF-α)-induced c-Jun kinase activation, c-Jun expression, and apoptosis. JNK1 and JNK2 participates in the survival of neuronal cells.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable