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J4205

JK184

Name: JK184
Brand: SIGMA

≥98% (HPLC), powder

别名:

N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine

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About This Item

经验公式（希尔记法）:

C₁₉H₁₈N₄OS

CAS号:

315703-52-7

分子量:

350.44

分類程式碼代碼:

51111800

PubChem物質ID:

329815733

NACRES:

NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

off-white to light brown

溶解度

DMSO: ≥20 mg/mL

儲存溫度

room temp

SMILES 字串

CCOc1ccc(Cc2nc(cs2)-c3c(C)nc4ccccn34)cc1

InChI

1S/C20H19N3OS/c1-3-24-16-9-7-15(8-10-16)12-19-22-17(13-25-19)20-14(2)21-18-6-4-5-11-23(18)20/h4-11,13H,3,12H2,1-2H3

InChI 密鑰

CBKFVRMNQUKWPX-UHFFFAOYSA-N

生化／生理作用

JK184 is a Hedgehog signaling pathway antagonist. JK184 blocks sonic hedgehog induced Gli transcription with an IC50 of 30 nM, and disrupts hedgehog signalling by inhibition of alcohol dehydrogenase 7 and depolymerization of mirotubules.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

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Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells.

Helen O Oladapo et al.

Cancer letters, 411, 136-149 (2017-10-03)

Activation of the Hedgehog (Hh) pathway effector GLI1 is linked to tumorigenesis and invasiveness in a number of cancers, with targeting of GLI1 by small molecule antagonists shown to be effective. We profiled a collection of GLI antagonists possessing distinct

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