化驗
≥98% (HPLC)
形狀
solid
顏色
white
溶解度
H2O: ~10 mg/mL
儲存溫度
2-8°C
SMILES 字串
CCCCN1C2CCC1CC(C2)OC(c3ccc(F)cc3)c4ccc(F)cc4
生化／生理作用
Selective antagonist of the cocaine site on dopamine transporter.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
G E Agoston et al.
Journal of medicinal chemistry, 40(26), 4329-4339 (1998-01-22)
A series of N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues has been prepared that function as dopamine uptake inhibitors. The N-methylated analogue of this series had a significantly higher affinity for the dopamine transporter than the parent compound, N-methyl-3 alpha- (diphenylmethoxy)tropane (benztropine, Cogentin).
Rajeev I Desai et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(8), 1889-1893 (2005-02-25)
There is a large unmet medical need for cocaine addiction treatments. Studies have indicated that the dopamine transporter (DAT) is the primary biological target of cocaine, and most drugs that have DAT affinity have behavioral effects like those of cocaine.
Sangeeta Raje et al.
The Journal of pharmacology and experimental therapeutics, 307(2), 801-808 (2003-09-11)
The N-substituted 3alpha-[bis(4'-fluorophenyl)methoxy]tropanes (AHN 2-003, AHN 1-055, AHN 2-005, and JHW 007) bind with high affinity to the dopamine transporter and inhibit dopamine uptake more potently than cocaine, but they demonstrate behavioral profiles in animal models of psychostimulant abuse that
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