生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~80 kDa
种属反应性
human
浓度
~1.0 mg/mL
技术
western blot: 0.5-1 μg/mL
UniProt登记号
应用
research pathology
运输
dry ice
储存温度
−20°C
基因信息
human ... IKBKE(9641)
一般描述
IKK-epsilon/IKK-I belongs to IκB kinase complex and express mainly in immune cells. IKK-I express in response to proinflammatory cytokines such as tumor necrosis factor-α, IL-, IL-6 and stimulate NF-κB activation, hence referred as inducible IκB kinase . Polyclonal anti-IKK epsilon/IKK-I c-terminal antibody can be used in immunoblotting to detect human IKK epsilon/IKK-I. Anti-IKK epsilon/IKK-I antibodies can react specifically with human IKK epsilon/IKK-I and show no cross reactivity with IKK α, IKK β and IKK γ.
特异性
The antibody show no cross-reactivity to IKKα, IKKβ, or IKKγ.
免疫原
Synthetic peptide corresponding to amino acids 701-716 of human IKK-epsilon/IKK-I conjugated to KLH.
应用
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Polyclonal anti-IKK epsilon/IKK-I c-terminal antibody can be used in immunoprecipitation and western blot.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
T Shimada et al.
International immunology, 11(8), 1357-1362 (1999-07-28)
Using the suppression subtractive hybridization technique, we isolated a novel kinase, IKK-i, whose message is drastically induced by lipopolysaccharide (LPS) in the mouse macrophage cell line RAW264. 7. The predicted protein contains the kinase domain in its N-terminus, which shares
Jian-Ping Guo et al.
The Journal of biological chemistry, 285(6), 3676-3684 (2009-11-27)
IKKepsilon has recently been identified as a breast cancer oncogene. Elevated levels of IKKepsilon are associated with cell survival and growth. Here, we show that IKKepsilon interacts with and phosphorylates estrogen receptor alpha (ERalpha) on serine 167 in vitro and
Suhu Liu et al.
Blood advances, 2(23), 3428-3442 (2018-12-07)
To identify novel therapeutic targets in acute myeloid leukemia (AML), we examined kinase expression patterns in primary AML samples. We found that the serine/threonine kinase IKBKE, a noncanonical IkB kinase, is expressed at higher levels in myeloid leukemia cells compared
R T Peters et al.
Molecular cell, 5(3), 513-522 (2000-07-06)
Here we report the identification of a novel PMA-inducible IkappaB kinase complex, distinct from the well-characterized high-molecular weight IkappaB kinase complex containing IKKalpha, IKKbeta, and IKKgamma. We have characterized one kinase from this complex, which we designate IKKepsilon. Although recombinant
Israel Cañadas et al.
Nature medicine, 24(8), 1143-1150 (2018-07-25)
Mesenchymal tumor subpopulations secrete pro-tumorigenic cytokines and promote treatment resistance1-4. This phenomenon has been implicated in chemorefractory small cell lung cancer and resistance to targeted therapies5-8, but remains incompletely defined. Here, we identify a subclass of endogenous retroviruses (ERVs) that
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