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Merck

I1786

Sigma-Aldrich

ID-8

≥98% (HPLC)

别名:

1-(4-甲氧苯基)-2-甲基-3-硝基-1H-吲哚-6-醇

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About This Item

经验公式(希尔记法):
C16H14N2O4
分子量:
298.29
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

yellow

溶解度

DMSO: ≥10 mg/mL

儲存溫度

2-8°C

SMILES 字串

COc1ccc(cc1)-n2c(C)c([N+]([O-])=O)c3ccc(O)cc23

InChI

1S/C16H14N2O4/c1-10-16(18(20)21)14-8-5-12(19)9-15(14)17(10)11-3-6-13(22-2)7-4-11/h3-9,19H,1-2H3

InChI 密鑰

VVZNWYXIOADGSW-UHFFFAOYSA-N

一般說明

ID-8 是双特异性酪氨酸磷酸化调节激酶 1A (DYRK1A) 的抑制剂。

生化/生理作用

ID-8 在体外维持小鼠胚胎干细胞 (ESC) 的自我更新和多潜能性。以稳定的速度刺激增殖(在添加 10 μg/ml 的无血清培养基中观察到)M 为期 30 天)。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3


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Stefan Hindel et al.
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The purpose of our study was to validate perfusion quantification in a low-perfused tissue by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with shared k-space sampling using a blood pool contrast agent. Perfusion measurements were performed in a total of seven
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Current molecular pharmacology, 9(3), 272-279 (2015-05-27)
Despite their high degree of identity and even higher homology, the two Kat3 transcriptional coactivators, CBP and p300, have distinct functions, particularly within the Wnt/β-catenin signaling cascade. ICG-001, by directly binding to CBP but not p300, inhibits CBP/β-catenin transcription and
A High-Throughput Screen Identifies DYRK1A inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation
Monteiro M B, et al.
Journal of the American Society of Nephrology, ASN-2018040392 (2018)
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Annals of translational medicine, 8(12), 752-752 (2020-07-11)
Paclitaxel is a widely used clinical first line chemotherapy drug for ovarian carcinoma. Tanshinone I (Tan-I) is one of the vital fat-soluble components, which derived from Chinese herbal medicine, Salvia miltiorrhiza Bunge. Herein, we evaluated whether Tan-I could enhance the
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In Chinese herbal medicine, Tanshinone IIA (Tan-IIA) is one of the main compounds extracted from Salvia miltiorrhiza Bunge. Tan-IIA has been demonstrated to inhibit the growth of various tumors. However, the detailed molecular and cellular mechanisms of the antitumor effect

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