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Merck

I123

Sigma-Aldrich

ICI 216,140

>95%, solid

别名:

(CH3)2CHCO-His-Trp-Ala-Val-D-Ala-His-Leu-NHCH3

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About This Item

经验公式(希尔记法):
C45H65N13O8
分子量:
916.08
MDL號碼:
分類程式碼代碼:
12352200

化驗

>95%

形狀

solid

顏色

white

儲存溫度

−20°C

SMILES 字串

CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)C(C)C)C(C)C

生化/生理作用

Potent in vivo receptor antagonist of the bombesin/gastrin releasing peptide receptor.

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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B J Campbell et al.
Regulatory peptides, 49(3), 249-255 (1994-01-13)
The mechanisms of action of gastrin and gastrin releasing peptide (GRP) in stimulating gastric acid secretion were examined in the anaesthetized turkey. Gastrin and GRP produced dose-dependent increases in acid secretion that were inhibited by the gastrin/CCK-B antagonist CI988. The
R R Ryan et al.
European journal of pharmacology, 306(1-3), 307-314 (1996-06-13)
We examined the effect of two des-Met-bombesin analogues, [(CH3)2CHCO-His-Trp-Ala-Val-D-Ala-His-Leu-NHCH3] (ICI 216140) and [D-Phe6,des-Met14]bombesin(6-14) ethylamide (DPDM-bombesin ethylamide), on neuromedin B-induced Ca2+ and [3H]arachidonate release in BALB 3T3 cells transfected with human neuromedin B receptors. ICI 216140 and DPDM-bombesin ethylamide both stimulated
R R Ryan et al.
Peptides, 14(6), 1231-1235 (1993-11-01)
We examined the profile of two bombesin (BN) antagonists, (CH3)2CHCO-His-Trp-Ala-Val-D-Ala-His-Leu-NHCH3] (ICI 216140) and [D-Phe6,des-Met14]BN(6-14)ethylamide (DPDM-BN EA), against neuromedin B-induced Ca2+ mobilization in the small cell lung cancer (SCLC) line NCI-H345. Neuromedin B (NMB), a BN-like peptide sharing sequence homology with
B Campbell et al.
The American journal of physiology, 261(1 Pt 1), G16-G21 (1991-07-01)
Endocrine cells in the acid-secreting part of the avian stomach, the proventriculus, contain two forms of gastrin-releasing peptide (GRP) of 27 and 6 residues, respectively. We have examined the actions of exogenous GRP-27 and GRP-6 and endogenously released GRP in
R Camble et al.
Life sciences, 45(17), 1521-1527 (1989-01-01)
The GRP receptor mediated growth response in Swiss 3T3 cells has been used to identify BN/GRP antagonists. Analysis of bombesin antagonism by substance P analogues and by truncated GRP analogues revealed that deletion of the C-terminal methionine residue was important

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