跳转至内容
Merck
所有图片(1)

主要文件

查看所有文档

I122

Sigma-Aldrich

ICI 204,448 hydrochloride

solid

别名:

(±)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride, R,S-[3-[1-[[(3,4-Dichlorophenyl)acetyl]methylamino]-2-(1-pyrrolidinyl)ethyl] phenoxy]-acetic acid hydrochloride

登录查看公司和协议定价
所有图片(1)

About This Item

经验公式（希尔记法）:
C23H26Cl2N2O4 · HCl
CAS号:
121264-04-8
分子量:
501.83
MDL编号:
MFCD00153814
UNSPSC代码:
12352200
PubChem化学物质编号:
24278040
NACRES:
NA.77

表单

solid

颜色

white

溶解性

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 12 mg/mL
dilute sodium carbonate: 4 mg/mL
H2O: 4.5 mg/mL

SMILES字符串

Cl[H].CN(C(CN1CCCC1)c2cccc(OCC(O)=O)c2)C(=O)Cc3ccc(Cl)c(Cl)c3

InChI

1S/C23H26Cl2N2O4.ClH/c1-26(22(28)12-16-7-8-19(24)20(25)11-16)21(14-27-9-2-3-10-27)17-5-4-6-18(13-17)31-15-23(29)30;/h4-8,11,13,21H,2-3,9-10,12,14-15H2,1H3,(H,29,30);1H

InChI key

FNDGLVOYAQNQPE-UHFFFAOYSA-N

基因信息

human ... OPRK1(4986)

正在寻找类似产品? 访问 产品对比指南

生化/生理作用

κ opioid receptor agonist that does not cross the blood-brain barrier.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our 文件 section.

如需帮助，请联系 客户支持

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Scott M Rawls et al.
Pharmacology, 74(2), 79-83 (2005-02-03)
ICI 204448, a selective kappa-opioid agonist with limited CNS access, can be used to discriminate central and peripheral opioid actions on physiological systems such as pain and thermoregulation. Therefore, we investigated the effect of ICI 204448 (2.5, 5, and 10
Jennifer L Werkheiser et al.
European journal of pharmacology, 547(1-3), 101-105 (2006-09-02)
Icilin is a cooling agent that precipitates vigorous wet-dog shakes in rats after acute i.p. administration. Recent research has emphasized the peripheral agonist properties (e.g. activation of transient receptor potential channels, TRPM8 and TRPA1) of icilin rather than its unusual
H Keïta et al.
European journal of pharmacology, 277(2-3), 275-280 (1995-04-24)
The antinociceptive effect of intraplantar (i.pl.) ICI 204448 ((R,S)-N-[2-(N-methyl-3,4-dichloro-phenylacetamido)-2-(3-carbox yph enyl)- ethyl]pyrrolidine hydrochloride)) (20, 30, 40 and 50 micrograms), a kappa-opioid receptor agonist which has limited access to the central nervous system, was studied in a well-established rat model of
J S Shaw et al.
British journal of pharmacology, 96(4), 986-992 (1989-04-01)
1. A number of compounds were evaluated in an attempt to identify a kappa-opioid receptor agonist with limited access to the central nervous system. 2. Quaternary derivatives of the kappa-opioid agonists tifluadom, U-50488H and ethylketocyclazocine were essentially devoid of opioid
M McIntosh et al.
European journal of pharmacology, 210(1), 37-44 (1992-01-07)
The antiarrhythmic activities of 16-methylcyprenorphine (M8008), nor-binaltorphimine (NBT) and naltrexone, which are relatively specific opioid receptor antagonists for delta, kappa and mu receptors, respectively, were examined during the 30 min following coronary artery occlusion in anaesthetised rats. The haemodynamic and
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门