生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
产品线
Prestige Antibodies® Powered by Atlas Antibodies
表单
buffered aqueous glycerol solution
种属反应性
human
技术
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:200-1:500
免疫原序列
SPAASEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLEREQNGDSHHSGDWRGPSRDSLPLPVRSRK
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... GPSM1(26086)
一般描述
G-protein-signaling modulator 1 (GPSM1) is also called activator of G protein signalling 3 (AGS3). The GPSM1 gene is mapped to human chromosome 9q34.3. AGS3 has a N-terminal domain with seven tetratri-copeptides (TPR) repeats and the C-terminal domain with four G-protein regulatory motifs (GPR) or GoLocomotifs. Brain and testes express AGS3 in high levels.
免疫原
G-protein signaling modulator 1 recombinant protein epitope signature tag (PrEST)
应用
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
生化/生理作用
G-protein-signaling modulator 1 (GPSM1) or activator of G protein signalling 3 (AGS3) functions to regulate G protein signalling. AGS3 functions to orient mitotic spindle and modulates development of cerebral cortical progenitor cells during neurogenesis. The GPR motif of AGS3 cytokine may regulate cytokine production in airway inflammation. It also regulates autophagic pathway and protein trafficking. AGS3 is down regulated human esophageal squamous cell carcinoma. AGS3 is also less expressed in multiple myeloma. Abnormal expression of AGS3 in renal epithelium is implicated in polycystic kidney disease (PKD).(10) Defects in AGS3 gene locus is implicated in MORM syndrome (mental retardation, truncal obesity, retinal dystrophy and micropenis).
特点和优势
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
联系
Corresponding Antigen APREST82026
外形
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
法律信息
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Regulation of airway inflammation by G-protein regulatory motif peptides of AGS3 protein
Choi ILW, et al.
Scientific Reports, 6(5), 27054-27054 (2016)
A specific role of AGS3 in the surface expression of plasma membrane proteins
Groves B, et al.
Proceedings of the National Academy of Sciences of the USA, 104(46), 18103-18108 (2007)
The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells
Pattingre S, et al.
The Journal of Biological Chemistry (2003)
AGS proteins, GPR motifs and the signals processed by heterotrimeric G proteins
Lanier SM
Biology of the Cell, 96(5), 369-372 (2004)
G protein betagamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors
Sanada K and Tsai L
Cell, 122(1), 119-131 (2005)
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