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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
產品線
Prestige Antibodies® Powered by Atlas Antibodies
形狀
buffered aqueous glycerol solution
物種活性
human
加強驗證
orthogonal RNAseq
independent
Learn more about Antibody Enhanced Validation
技術
immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:1000-1:2500
免疫原序列
AKKRFKDKSSEEAVREVHRLIEGKAPIISGVTKAISSPTVSRLTDTTKFTGSHK
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... TPPP(11076)
一般說明
Tubulin polymerization promoting protein (TPPP), also known as p25, is expressed in myelinating oligodendrocytes. TPPP is mapped to human chromosome 5p15.33. It has a p25 domain and is a disordered protein.
免疫原
tubulin polymerization promoting protein
應用
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
生化／生理作用
Tubulin polymerization promoting protein (TPPP) regulates oligodendrocyte differentiation. It interacts with tubulinand regulates microtubule bundle formation. Phosphorylation of TPPP at threonine or serine residue by mitogen-activated protein kinase 2 or by LIM kinase (LIMK) impactstubulin polymerization functionality. High expression of TPPP favors acetylation of microtubules. Deletion in the gene locus of TPPP may be implicated in the pathogenesis of cerebellar hypoplasia and facial dysmorphism in fetus. Mutations in the TPPP gene contributes to tumor progression in small cell lung cancer. TPPP localization with α-synuclein may help in the understanding neurodegeneration in Parkinson′s and Alzheimer′s diseases. TPPP promotes abnormal microtubule assemblies in alpha-synucleinopathies.
特點和優勢
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
聯結
Corresponding Antigen APREST80111
外觀
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
法律資訊
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6
Tokesi N, et al.
The Journal of Biological Chemistry, 285(20), 17896-17906 (2010)
P25alpha tubulin polymerization promoting protein expression by myelinating oligodendrocytes of the developing rat brain
Skjoerringe T, et al.
Journal of Neurochemistry, 99(1), 333-342 (2006)
Jacques Gilloteaux et al.
Ultrastructural pathology, 45(2), 128-157 (2021-06-23)
A murine osmotic demyelination syndrome (ODS) model of the central nervous system included the relay thalamic ventral posterolateral (VPL) and ventral posteromedial (VPM) nuclei. Morphologic comparisons between treatments have revealed oligodendrocyte changes and, already 12 hours following the osmolality restoration, some
The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules
Acevedo K, et al.
Experimental Cell Research, 313(20), 4091-4106 (2007)
TPPP/p25: from unfolded protein to misfolding disease: prediction and experiments
Orosz F, et al.
Biology of the Cell, 96(9), 701-711 (2004)
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