生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
產品線
Prestige Antibodies® Powered by Atlas Antibodies
形狀
buffered aqueous glycerol solution
物種活性
human
技術
immunohistochemistry: 1:50- 1:200
免疫原序列
GSDSPHRTSTSDLVEVPEEANGPGGGYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTY
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... STAC(6769)
一般說明
Src homology 3 and cysteine-rich domain-containing protein (STAC) has tandem Src homology 3 (SH3) and cysteine rich domains. The STAC gene is mapped to human chromosome 3p22−p24 and the protein is expressed in neurons.
免疫原
SH3 and cysteine rich domain recombinant protein epitope signature tag (PrEST)
應用
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
生化／生理作用
Src homology 3 and cysteine-rich domain-containing protein (STAC1) interacts with calcium channels using the tandem SH3 domain regions. STAC modulates calcium channels membrane expression and neuronal excitability in nerve cells. STAC1 expression may have impact on learning process.
特點和優勢
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
聯結
Corresponding Antigen APREST79384
外觀
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
法律資訊
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
A Cav3. 2/Stac1 molecular complex controls T-type channel expression at the plasma membrane
Rzhepetskyy Y, et al.
Channels (Austin, Tex.), 10(5), 346-354 (2016)
Human and mouse chromosomal mapping of Stac, a neuron-specific protein with an SH3 domain
Kawai J, et al.
Genomics, 47(1), 140-142 (1998)
Stac, a novel neuron-specific protein with cysteine-rich and SH3 domains
Suzuki H, et al.
Biochemical and Biophysical Research Communications, 229(3), 902-909 (1996)
Structural insights into binding of STAC proteins to voltage-gated calcium channels
Yuen SM, et al.
Proceedings of the National Academy of Sciences of the USA, 114(45), E9520-E9528 (2017)
Genome-wide association studies of placebo and duloxetine response in major depressive disorder
Maciukiewicz M, et al.
The Pharmacogenomics Journal, 18(3), 406-412 (2018)
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