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COO原产地证书/COA分析证书

H6161

[甘氨酸 ¹⁴]- 人蛋白 G

Name: [甘氨酸 <SUP> 14 </SUP>]- 人蛋白 G
Brand: SIGMA

≥95% (HPLC), powder

别名:

S14G-humanin, HNG

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About This Item

MDL號碼:

MFCD03787971

分類程式碼代碼:

12352209

NACRES:

NA.32

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SML2899

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658550

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SML2836

Lixisenatide

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B1427

H-89 二盐酸盐水合物

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MAK052

ALT 活性测定

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F5881

弗氏完全佐剂

生物源

human

品質等級

200

化驗

≥95% (HPLC)

形狀

powder

分子量

2654.2-2660.2 Da

儲存條件

(Keep container tightly closed in a dry and well-ventilated place)

技術

activity assay: suitable

溶解度

water: 1.00-1.04 mg/mL, clear, colorless

運輸包裝

dry ice

儲存溫度

−20°C

Amino Acid Sequence

Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala

一般說明

研究领域：神经科学

[Gly14]-人源蛋白（HNG）属于线粒体衍生肽家族。HNG（人蛋白-G）是人源蛋白的类似物，由 S14G（丝氨酸-14-甘氨酸）突变产生。HNG 表现出 1000 倍的更强活性。

應用

[Gly14]-人源蛋白 G 人已被用于：

与硼替佐米一起进行药理学抑制研究，以治疗小鼠，限制硼替佐米毒副作用
研究其对高糖（HG）诱导的内皮细胞（EC）凋亡的影响
利用 SH-SY5Y 神经母细胞瘤细胞在体外氧-糖剥夺/复氧（OGD/R）模型中研究其神经保护作用

在新生臂丛神经损伤（NBPI）小鼠模型中，硼替佐米治疗期间，[甘氨酸¹⁴]-人源蛋白 G 已被用于限制毒性。它还被用于人类来源的神经母细胞瘤细胞系的细胞培养。

生化／生理作用

[Gly14]-人源蛋白（HNG）刺激细胞生长、增殖和细胞周期进展。它增强激酶、转运蛋白、跨膜受体、转录和翻译调节因子等蛋白质。与天然 HN 相比，HNG 在体外表现出强烈的神经保护作用。研究表明，它在体外和体内都是一种有效的细胞保护剂。HNG 被发现可以防止高糖（HG）诱导的内皮细胞（EC）凋亡。它被证明可以抑制血管平滑肌细胞（VSMCs）中 AngII 诱导的表型转换。

内源性救援因子通过广泛的家族性阿尔茨海默病基因和aβ消除神经细胞死亡

抗體

产品编号

说明

价格

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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[Gly14]-Humanin inhibits an angiotensin II-induced vascular smooth muscle cell phenotypic switch via ameliorating intracellular oxidative stress.

Yi Xie et al.

Human & experimental toxicology, 41, 9603271221136208-9603271221136208 (2022-10-27)

Angiotensin II (AngII) is involved in the pathogenesis of hypertensive artery remodeling by inducing a phenotypic switch in vascular smooth muscle cells [Gly14]-Humanin (HNG), a humanin analogue, exerts potent cytoprotective effects both in vitro and in vivo. This study aimed

Proteasome inhibition preserves longitudinal growth of denervated muscle and prevents neonatal neuromuscular contractures.

Sia Nikolaou et al.

JCI insight, 4(23) (2019-10-30)

Muscle contractures are a prominent and disabling feature of many neuromuscular disorders, including the 2 most common forms of childhood neurologic dysfunction: neonatal brachial plexus injury (NBPI) and cerebral palsy. There are currently no treatment strategies to directly alter the

S14G-Humanin ameliorates ovalbumin-induced airway inflammation in asthma mediated by inhibition of toll-like receptor 4 (TLR4) expression and the nuclear factor κ-B (NF-κB)/early growth response protein-1 (Egr-1) pathway.

Bo Su et al.

Aging, 15(14), 6822-6833 (2023-07-15)

Asthma is a chronic inflammatory disease with a high morbidity rate in children and significantly impacts their healthy growth. It is reported that Th2 cell-mediated airway inflammation and activated oxidative stress are involved in the pathogenesis of asthma. S14G-humanin (HNG)

Cytoprotective role of S14G-humanin (HNG) in ultraviolet-B induced epidermal stem cells injury

Wang X, et al.

Biomedicine and Pharmacotherapy, 110 (2019)

Neuroprotective effect of G

Guangsheng Gao et al.

Neurological research, 39(10), 895-903 (2017-07-20)

Humanin (HN) has been identified to suppress neuron death. Gly Rats were randomly divided into 13 groups: Sham group, GI groups and HNG groups. Both GI group and HNG groups included six time points (1, 3, 6, 12, 24, and

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[甘氨酸 ¹⁴]- 人蛋白 G