重组
expressed in baculovirus infected Sf9 cells
质量水平
产品线
PRECISIO® Kinase
方案
≥70% (SDS-PAGE)
表单
buffered aqueous glycerol solution
比活
172-232 nmol/min·mg
分子量
~110 kDa
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... HIPK4(147746)
一般描述
HIPK4 (homeodomain-interacting protein kinase 4) is present in the lungs and white adipose tissues. The protein mainly localizes in the cytoplasm. However, a weak signal is also present in the nucleus.
生化/生理作用
HIPK4 (homeodomain-interacting protein kinase 4) is serine/threonine kinase protein. HIPK4-mediated phosphorylation of p53 is crucial for p53-associated transcriptional repression.
外形
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
法律信息
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Valeria Di Stefano et al.
Experimental cell research, 293(2), 311-320 (2004-01-20)
HIPK2 is a member of a novel family of nuclear serine-threonine kinases identified through their ability to interact with the Nkx-1.2 homeoprotein. The physiological role of these kinases is largely unknown, but we have recently reported on the involvement of
Shigeki Arai et al.
FEBS letters, 581(29), 5649-5657 (2007-11-21)
We describe here the cloning and characterization of a novel mouse homeodomain-interacting protein kinase (HIPK)-like gene, Hipk4. Hipk4 is expressed in lung and in white adipose tissue and encodes a 616 amino acid protein that includes a serine/threonine kinase domain.
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