生物源
chicken
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
mouse, rat, human
製造商／商標名
Genway 15-288-22346
技術
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... BCAS2(10286)
免疫原
Immunogen Sequence: GI # 5031653, sequence 1-225
Recombinant breast carcinoma amplified sequence 2
應用
Anti-BCAS2 antibody produced in chicken is suitable western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化／生理作用
Pre-mRNA-splicing factor SPF27 is a protein encoded by the BCAS2 gene in humans and is mapped to chromosome 1p13.3-21 region. It codes for a nuclear protein. BCAS2 is a novel gene up-regulated by amplification in human breast cancer cell lines. It acts as a transcriptional coactivator of estrogen receptor. It directly interacts with p53 to reduce p53 transcriptional activity and consistently decreases p53 protein in the absence of DNA damage. BCAS2 is a small nuclear protein (26kDa) and a novel negative regulator of p53. It is a potential molecular target for cancer therapy.
外觀
Solution in phosphate buffered saline containing 0.02% sodium azide.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Ping-Chang Kuo et al.
Cancer research, 69(23), 8877-8885 (2009-11-12)
Breast cancer amplified sequence 2 (BCAS2) was reported previously as a transcriptional coactivator of estrogen receptor. Here, we report that BCAS2 directly interacts with p53 to reduce p53 transcriptional activity by mildly but consistently decreasing p53 protein in the absence
Nicolai Maass et al.
Cancer letters, 185(2), 219-223 (2002-08-10)
BCAS2 is a novel gene isolated from breast cancer cell line by differential display technique. Previously we reported that BCAS2 gene is localized on chromosome 1p13.3-21 and is up-regulated by gene amplification in breast cancer cell lines MCF-7 and BT-20.
K Nagasaki et al.
Cancer letters, 140(1-2), 219-226 (1999-07-14)
Screening for differentially expressed genes in cancer cell lines by the RNA differential display (DD) technique identified a novel mRNA that encodes a 26-kDa protein and is up-regulated in MCF-7 and BT-20 breast cancer cells. The predicted amino acid sequence
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