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Merck
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文件

G9137

Sigma-Aldrich

Gly-Pro 4-甲氧基-β-萘酰胺

dipeptidylpeptidase IV substrate

别名:

H-Gly-Pro-4MbNA

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About This Item

经验公式（希尔记法）:
C18H21N3O3
CAS号:
42761-76-2
分子量:
327.38
MDL號碼:
MFCD00037726
分類程式碼代碼:
12352204
PubChem物質ID:
24895363
NACRES:
NA.32

化驗

≥98% (TLC)

形狀

powder

溶解度

ethanol: 50 mg/mL, clear, colorless to faintly yellow

儲存溫度

−20°C

SMILES 字串

COc1cc(NC(=O)C2CCCN2C(=O)CN)cc3ccccc13

InChI

1S/C18H21N3O3/c1-24-16-10-13(9-12-5-2-3-6-14(12)16)20-18(23)15-7-4-8-21(15)17(22)11-19/h2-3,5-6,9-10,15H,4,7-8,11,19H2,1H3,(H,20,23)

InChI 密鑰

LSZPYDQEJZWJIJ-UHFFFAOYSA-N

應用

Gly-Pro 4-methoxy-β-naphthylamide has been used as a substrate to evaluate the dipeptidyl peptidase-4 (DPP4) enzymatic activity.

包裝

Bottomless glass bottle. Contents are inside inserted fused cone.

基底

Substrate for Dipeptidyl Aminopeptidase IV

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Gerd Luippold et al.
Diabetes research and clinical practice, 143, 199-203 (2018-07-22)
The two dipeptidyl peptidase (DPP)-4 inhibitors, linagliptin and sitagliptin, were shown to exert different binding kinetics in vitro. Twenty-four hours after oral dosing particularly in vivo inhibition of renal-specific DPP-4 activity was more sustained in Sprague Dawley rats after exposure
Wesley Mah et al.
The American journal of pathology, 187(8), 1717-1735 (2017-06-24)
Compared to skin, wound healing in oral mucosa is faster and produces less scarring, but the mechanisms involved are incompletely understood. Studies in mice have linked high expression of CD26 to a profibrotic fibroblast phenotype, but this has not been
Wesley Mah et al.
The American journal of pathology, 187(8), 1717-1735 (2017-06-24)
Compared to skin, wound healing in oral mucosa is faster and produces less scarring, but the mechanisms involved are incompletely understood. Studies in mice have linked high expression of CD26 to a profibrotic fibroblast phenotype, but this has not been
Anna-Lena Mayer et al.
British journal of pharmacology, 178(4), 878-895 (2020-11-11)
Dipeptidyl peptidase 4 (DPP-4) inhibitors are a class of oral glucose-lowering drugs used in the treatment of type 2 diabetes. In a pilot study using human kidney biopsies, we observed high DPP-4 expression in early crescent formation. This glomerular lesion

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