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生物源
human blood (type MN)
品質等級
形狀
lyophilized powder
溶解度
soluble 1.00-1.10 mg/mL
H2O: soluble, clear to hazy
UniProt登錄號
儲存溫度
−20°C
基因資訊
human ... GYPA(2993)
一般說明
Glycophorin (GYPA), a sialoglycoprotein, is present in human erythrocytes that carry antigens M and N of the MN blood group. The GYPA gene is mapped to human chromosome 4q31.21.
Glycophorin A cconsists of a glycosylated extracellular domain, a single transmembrane α-helix and a cytoplasmic COOH-terminal domain.
應用
Glycophorin A (GpA) is used as a model system for extensive experimental, theoretical, and simulation studies focusing on TM protein association. Glycophorin A is used to study the mechanism of kinase activation in the receptor for colony-stimulating factor 1. It is used to analyse glycoproteins separated by two-dimensional gel electrophoresis.
Glycophorin Predominantly glycophorin A from blood type MN has been used:
- as a standard in Amide-80 column size-based separation for the characterization of plasma-type O-linked sugar chains
- to screen the P. falciparum phage library using biopanning method,
- as a phosphocholine-free component to test its reactivity with antibodies over a saccharide-bound enzyme-linked immunosorbent assay (ELISA)
生化／生理作用
Glycophorin (GYPA) is involved in the mode of entry of the Plasmodium falciparum parasite into erythrocytes. It is also implicated in intraplaque hemorrhage as well as in the macrophage infiltration in coronary atheromas.
A membrane glycoprotein with several isoforms that interact with other membrane proteins to confer shape and antigenicity to erythrocytes.
免責聲明
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Hajime Mizukami et al.
Journal of human genetics, 50(12), 667-670 (2005-10-06)
Ten alleles (five M and five N alleles) of the MN blood group system with normal antigenicity were found by sequencing the glycophorin A (GPA) gene. This study demonstrates the systematic classification of these alleles to major or minor variations
N H Packer et al.
Electrophoresis, 19(6), 981-988 (1998-06-25)
Two-dimensional (2-D) electrophoresis is the preferred method for separating the glycoforms of proteins. The isoforms usually present as 'trains' of spots in the first dimension and may also differ in molecular weight. The primary goal for analyzing the carbohydrate content
Possible exacerbation of myasthenia gravis by ciprofloxacin.
B Moore et al.
Lancet (London, England), 1(8590), 882-882 (1988-04-16)
Alba Fernández-Sánchez et al.
Immunology letters, 123(2), 125-131 (2009-05-12)
The immunization of BALB/c mice with heat-killed cells of Streptococcus mitis SK598 allowed the rescue of mouse monoclonal antibodies (mAbs) reactive with the pneumococcal cell wall C-polysaccharide backbone. We report for the first time the genetic and molecular characterization of
Santosh Kumar Patnaik et al.
Nucleic acids research, 40(Database issue), D1023-D1029 (2011-11-16)
Analogous to human leukocyte antigens, blood group antigens are surface markers on the erythrocyte cell membrane whose structures differ among individuals and which can be serologically identified. The Blood Group Antigen Gene Mutation Database (BGMUT) is an online repository of
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