所有图片(1)
About This Item
经验公式（希尔记法）:
C18H11ClN2O · xH2O
CAS号:
分子量:
306.75 (anhydrous basis)
MDL號碼:
分類程式碼代碼:
12352200
化驗
≥98% (HPLC)
形狀
solid
顏色
brick red
溶解度
H2O: <2 mg/mL
DMSO: ~20 mg/mL
儲存溫度
2-8°C
SMILES 字串
[Cl-].[H]O[H].O=C1c2ccccc2-[n+]3ccc4c([nH]c5ccccc45)c13
InChI
1S/C18H10N2O.ClH.H2O/c21-18-13-6-2-4-8-15(13)20-10-9-12-11-5-1-3-7-14(11)19-16(12)17(18)20;;/h1-10H;1H;1H2
InChI 密鑰
WPIOPGXRERNYSI-UHFFFAOYSA-N
生化／生理作用
Originally isolated from the marine sponge Thorectandra sp., fascaplysin chloride is a selective, potent inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50 = 0.35 μM). It is significantly less selective for Cdk6/D1 (IC50 = 3.4 μM) and not selective for the other Cdks and tyrosine kinases.
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources.
Nathaniel L Segraves et al.
Journal of natural products, 67(5), 783-792 (2004-05-29)
The fascaplysin class of compounds have been further investigated from six organisms consisting of four sponge collections (Fascaplysinopsis reticulata) and two tunicate collections (Didemnum sp.). This work is an extension of an earlier communication and reports the isolation of 12
Zhenyu Lu et al.
Bioorganic & medicinal chemistry, 19(22), 6604-6607 (2011-06-24)
A new fascaplysin analogue, 3-bromohomofascaplysin A (1), along with two known analogues, homofascaplysin A (2) and fascaplysin (3), were isolated from a Fijian Didemnum sp. ascidian. The absolute configurations of 3-bromohomofascaplysin A (1) and homofascaplysin A (2) were determined via
Y L Zheng et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 64(8), 527-533 (2009-11-26)
Novel anti-angiogenesis activity of fascaplysin via VEGF blockage was recently revealed by our previous study in addition to the reported cyclin-dependent kinase 4 (CDK4) selective inhibition. To uncover more details of this pharmacologically prospective property, this study further investigated whether
Jing Lin et al.
Cancer chemotherapy and pharmacology, 59(4), 439-445 (2006-07-04)
This study was to evaluate the correlation of two important strategies, namely, cell cycle proliferation arrest and anti-angiogenesis. We chose fascaplysin, a marine natural product with selective CDK4 selective inhibition activity, to study its potential anti-angiogenesis effects in vivo and
Sachin Mahale et al.
Bioorganic chemistry, 34(5), 287-297 (2006-08-15)
Tryptamine derivatives, a new structural class of cyclin dependent kinase 4 inhibitors, have been identified during extensive biological screening of synthetic molecules. The molecules were synthesized based on the structure of fascaplysin, which is not only a specific inhibitor of
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门