所有图片(1)
About This Item
经验公式（希尔记法）:
C17H30N2O5
CAS号:
分子量:
342.43
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
产品名称
E-64d, protease inhibitor
生物来源
synthetic (organic)
质量水平
方案
≥98% (TLC)
表单
powder
溶解性
methanol: water (1:1): 5 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C
InChI
1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1
InChI key
SRVFFFJZQVENJC-IHRRRGAJSA-N
基因信息
human ... CAPN1(823)
应用
E-64d已作为一种溶酶体抑制剂，被用于人类急性早幼粒细胞白血病NB4细胞 和Huh-7细胞中。它也已作为一种蛋白酶抑制剂，被用于游离钙生理酪氨酸溶液中，以用于对分离出的心脏样本的灌注。
生化/生理作用
E-64d是一种环氧琥珀酰肽，以及半胱氨酸蛋白酶组织蛋白酶B、钙蛋白酶1和2的抑制剂。 E-64d具有对组织蛋白酶B蛋白酶的抑制功能，可作为治疗颅脑外伤（TBI）和阿尔茨海默氏症′（AD）的潜在药物。它可抑制配子体表面抗原，从而减少恶性疟原虫卵囊的产生。
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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Extensive transcriptional activity occurring in intergenic regions of genomes has raised the question whether intergenic transcription represents the activity of novel genes or noisy expression. To address this, we evaluated cross-species and post-duplication sequence and expression conservation of intergenic transcribed
Ethambutol neutralizes lysosomes and causes lysosomal zinc accumulation
Yamada D, et al.
Biochemical and Biophysical Research Communications, 471(1), 109-116 (2016)
The cysteine protease inhibitor, E64d, reduces brain amyloid-beta and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, beta-secretase activity
Hook G, et al.
Journal of Alzheimer'S Disease, 26(2), 387-408 (2011)
Inhibition of Plasmodium falciparum oocyst production by membrane-permeant cysteine protease inhibitor E64d
Eksi S, et al.
Antimicrobial Agents and Chemotherapy, 51(3), 1064-1070 (2007)
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