所有图片(1)
About This Item
经验公式（希尔记法）:
C20H23N · HClO4
CAS号:
分子量:
377.86
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
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质量水平
药品控制
regulated under CDSA - not available from Sigma-Aldrich Canada
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
forensics and toxicology
veterinary
包装形式
neat
储存温度
2-8°C
SMILES字符串
OCl(=O)(=O)=O.C\C=C1/N(C)C(C)CC1(c2ccccc2)c3ccccc3
InChI
1S/C20H23N.ClHO4/c1-4-19-20(15-16(2)21(19)3,17-11-7-5-8-12-17)18-13-9-6-10-14-18;2-1(3,4)5/h4-14,16H,15H2,1-3H3;(H,2,3,4,5)/b19-4-;
InChI key
CBNJWAYHGKHAFJ-YOJQKEKBSA-N
一般描述
2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine perchlorate is a primary metabolite of methadone.
应用
2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine perchlorate has been used as a standard in the quantitative determination of of methadone and metabolites in human meconium using liquid chromatography coupled with atmospheric pressure chemical ionization tandem mass spectrometry technique (LC–APCI–MS/MS).
A metabolite of methadone, useful as a marker in GC-MS analyses.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
G I Kang et al.
Journal of chromatography, 231(2), 311-319 (1982-09-10)
The analysis of methadone and its metabolites in biological fluids by gas chromatography--mass spectrometry is described with deuterated methadone and metabolites as internal standards. The method allowed the determination of 20 ng methadone in 0.5 ml of plasma or saliva.
Determination of methadone, 2-ethylidene-1, 5-dimethyl-3, 3-diphenylpyrrolidine, 2-ethyl-5-methyl-3, 3-diphenylpyraline and methadol in meconium by liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry
Choo.ER, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 814, 369-373 (2005)
Mei-Han Huang et al.
Toxicology, 280(1-2), 1-9 (2010-11-26)
Methadone (Mtd) is a widely used opioid drug associated with the side effect of hyperprolactinemia. The mechanism of how Mtd induces prolactin secretion remains unclear. The effects of Mtd and its two main metabolites (EDDP: (±)-2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium percholarate and EMDP: 2-ethyl-5-methyl-3,3-dipnehyl-1-pyrroline)
Mathew George et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 8(4), 432-435 (2012-08-18)
Reports describing methadone overdose in adult and pediatric patient populations are not uncommon. Reports in the preterm neonate patient population, however, are infrequent even though the utilization of methadone in that population continues to increase. Significant age-related pharmacokinetic differences complicate
Cristiana Gambelunghe et al.
Annals of clinical and laboratory science, 43(1), 22-30 (2013-03-07)
It may be advantageous to use sweat, rather than blood or urine, to monitor individuals' drug exposure for the purposes of drug treatment programs, employment initiatives, and forensic investigations. Forty-eight patients receiving methadone at the Public Service for the Treatment
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