所有图片(1)
About This Item
经验公式（希尔记法）:
C12H12N2O2S
CAS号:
分子量:
248.30
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
表单
solid
颜色
light yellow
溶解性
DMSO: soluble 28 mg/mL
SMILES字符串
CSc1ccc(cc1)C(=O)C2=C(C)NC(=O)N2
InChI
1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16)
InChI key
ZJKNESGOIKRXQY-UHFFFAOYSA-N
基因信息
human ... PDE3A(5139) , PDE3B(5140)
生化/生理作用
Selective phosphodiesterase III (PDE3) inhibitor. Prevents the degradation of cAMP by PDE.
Selective phosphodiesterase III (PDE3) inhibitor. Prevents the degradation of cAMP by PDE. Increased cAMP results in enhanced contractility of the heart.
特点和优势
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Marco Metra et al.
European heart journal, 30(24), 3015-3026 (2009-08-25)
Use of inotropic agents in patients with heart failure (HF) has been limited by adverse effects on outcomes. However, administration of positive inotropes at lower doses and concomitant treatment with beta-blockers might increase benefit-risk ratio. We investigated the effects of
Stijn Schauvliege et al.
Veterinary anaesthesia and analgesia, 35(4), 306-318 (2009-06-16)
To evaluate the combined effects of enoximone and dobutamine on the cardiovascular system and respiratory gas exchange in isoflurane-anaesthetized ponies. Prospective, randomized, experimental study. Six ponies (286 +/- 52 kg), aged 5.0 +/- 1.6 years. After sedation (romifidine 80 microg
D Trenk et al.
Zeitschrift fur Kardiologie, 83 Suppl 2, 7-14 (1994-01-01)
Enoximone is an imidazole derivative which proved to be a selective inhibitor of the isoenzymes III/IV of the cAMP-specific phosphodiesterase. It has been shown in various experimental models that the drug exerts both positive inotropic and vasodilating properties which can
S Schauvliege et al.
Equine veterinary journal, 41(8), 778-785 (2010-01-26)
No studies have been reported on the effects of enoximone in anaesthetised colic horses. To examine whether enoximone improves cardiovascular function and reduces dobutamine requirement in anaesthetised colic horses. Forty-eight mature colic horses were enrolled in this prospective, randomised clinical
R C Dage et al.
Cardiology, 77 Suppl 3, 2-13 (1990-01-01)
Enoximone is an inotropic vasodilating agent. Its principal effects are positive inotropism and vasodilation, which are not accompanied by changes in myocardial oxygen consumption. An inotropic dose of enoximone increases the level of cyclic AMP in the isolated, blood-perfused dog
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门