D5321

D36 hydrate

≥98% (HPLC)

• 别名: 5-(2-methoxyphenyl)-1-(2-methylpropyl)-1H-Indole-3-acetamide Hydrate
• 经验公式（希尔记法）: C₂₁H₂₄N₂O₂ · xH₂O
• CAS号: 1228184-64-2
• 分子量: 336.43 (anhydrous basis)
• MDL编号: MFCD16875421
• UNSPSC代码: 51111800
• PubChem化学物质编号: 329798803

属性

• 方案: ≥98% (HPLC)
• 表单: powder
• 储存条件: desiccated
• 颜色: white to off-white
• 溶解性: DMSO: >10 mg/mL
• 创始人: GlaxoSmithKline
• 储存温度: 2-8°C
• SMILES字符串: O.COc1ccccc1-c2ccc3n(CC(C)C)cc(CC(N)=O)c3c2
• InChI: 1S/C21H24N2O2.H2O/c1-14(2)12-23-13-16(11-21(22)24)18-10-15(8-9-19(18)23)17-6-4-5-7-20(17)25-3;/h4-10,13-14H,11-12H2,1-3H3,(H2,22,24);1H2
• InChI key: ZERKAKHVUQMJPW-UHFFFAOYSA-N

说明

生化/生理作用

D36 is an androgen receptor (AR) allosteric antagonist with inverse agonist properties. D36 inhibits both wild-type and agonist-induced AR activity and antagonized AR in a hormone-refractory model.

特点和优势

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable