D1413

2′,3′-二脱氢-3′-脱氧胸苷

≥98% (TLC)

• 别名: Stavudine
• 经验公式（希尔记法）: C₁₀H₁₂N₂O₄
• CAS号: 3056-17-5
• 分子量: 224.21
• MDL编号: MFCD00132921
• UNSPSC代码: 12352200
• PubChem化学物质编号: 24278356
• NACRES: NA.77

属性

• 质量水平: 200
• 方案: ≥98% (TLC)
• 表单: powder
• 储存温度: −20°C
• SMILES字符串: CC1=CN([C@@H]2O[C@H](CO)C=C2)C(=O)NC1=O
• InChI: 1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-4,7-8,13H,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1
• InChI key: XNKLLVCARDGLGL-JGVFFNPUSA-N

说明

一般描述

2′,3′-Didehydro-3′-deoxythymidine (d4T), a pyrimidine analogue is the inhibitor of reverse transcriptase.

应用

2′,3′-Didehydro-3′-deoxythymidine has been used in cell treatment. It has also been used as a drug in Caenorhabditis elegans to study drug induced mitochondrial toxicity. It has also been used in the preclinical evaluation of GS-9160.

生化/生理作用

2′,3′-Didehydro-3′-deoxythymidine is a nucleoside analog, which inhibits HIV replication in vitro. Stavudine has the ability to enter the cells by non-facilitated diffusion. It possesses inhibitory activity against moloney murine leukemia virus, friend murine leukemia virus and simian immunodeficiency virus.

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 2
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable
• 个人防护装备: Eyeshields, Gloves, type N95 (US)