C9400

Calcium Ionophore A23187

• 别名: A23187, Antibiotic A 23187, Calimycin 半镁盐
• 经验公式（希尔记法）: C₂₉H₃₆Mg_0.5N₃O₆
• CAS号: 72124-77-7
• 分子量: 534.77
• Beilstein: 6765085
• MDL號碼: MFCD00151203
• 分類程式碼代碼: 12352202
• PubChem物質ID: 24893158
• NACRES: NA.77

属性

• 無菌: non-sterile
• 品質等級: 200
• 形狀: powder
• 抗生素活性譜: Gram-positive bacteria; fungi
• 作用方式: cell membrane | interferes
• 儲存溫度: 2-8°C
• SMILES 字串: CNc1ccc2oc(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@@H]([C@H](C)C[C@H]4C)[C@H](C)C(=O)c5ccc[nH]5)nc2c1C(=O)O[Mg]OC(=O)c6c(NC)ccc7oc(C[C@H]8O[C@@]9(CC[C@H]8C)O[C@@H]([C@H](C)C[C@H]9C)[C@H](C)C(=O)c%10ccc[nH]%10)nc67
• InChI: 1S/2C29H37N3O6.Mg/c2*1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35;/h2*6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35);/q;;+2/p-2/t2*15-,16-,17-,18-,22-,27+,29+;/m11./s1
• InChI 密鑰: XBWKBTZDBYFEMH-UIOMRPQBSA-L

说明

應用

Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase. Used to study effects of elevated intracellular calcium on mitochondrial function and intrinsic apoptosis.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302 + H312 + H332,H315,H319,H335
• 防範說明: P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• 危險分類: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves