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Merck

C6770

Sigma-Aldrich

卡巴多

别名:

2-(喹喔啉-2-亚甲基)肼-羧酸甲酯- N,N′-二氧化物

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About This Item

经验公式(希尔记法):
C11H10N4O4
CAS号:
分子量:
262.22
EC號碼:
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.85

形狀

powder

溶解度

1 M NaOH: 50 mg/mL

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

DNA synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

COC(=O)N\N=C\c1cn(=O)c2ccccc2n1=O

InChI

1S/C11H10N4O4/c1-19-11(16)13-12-6-8-7-14(17)9-4-2-3-5-10(9)15(8)18/h2-7H,1H3,(H,13,16)/b12-6+

InChI 密鑰

OVGGLBAWFMIPPY-WUXMJOGZSA-N

應用

卡巴多司已被用于抑制醛固酮的产生,研究产生志贺毒素的大肠杆菌(STEC)菌株的传播,以及比较不同的抗菌活性。

生化/生理作用

卡巴多司是一种喹喔啉二氧化氮抗生素,通常用在猪饲料中预防痢疾并提高饲料效率。它通过插入和诱导细菌基因组中的突变来抑制细菌。

其他說明

保存于密闭容器内,置于干燥通风处。

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 4 Oral - Carc. 1B - Flam. Sol. 1

儲存類別代碼

4.1B - Flammable solid hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

64.4 °F - closed cup

閃點(°C)

18 °C - closed cup


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分析证书(COA)

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Amisha D Shah et al.
Environmental science & technology, 40(23), 7228-7235 (2006-12-22)
The potential release of carbadox (CDX), a commonly used antibacterial agent in swine husbandry, into water systems is of a concern due to its carcinogenic and genotoxic effects. Until this study, the reactivity of carbadox (possessing quinoxaline N,N'-dioxide and hydrazone
Thaddeus B Stanton et al.
Applied and environmental microbiology, 74(10), 2950-2956 (2008-03-25)
Brachyspira hyodysenteriae is an anaerobic spirochete and the etiologic agent of swine dysentery. The genome of this spirochete contains a mitomycin C-inducible, prophage-like gene transfer agent designated VSH-1. VSH-1 particles package random 7.5-kb fragments of the B. hyodysenteriae genome and
M C Walsh et al.
Journal of animal science, 90(8), 2599-2608 (2012-02-22)
The objective of this study was to evaluate the effects of water-delivered, direct-fed microbials (DFM) or organic acids on intestinal morphology and active nutrient absorption in weanling pigs after deliberate Salmonella infection. Pigs (n = 88) were weaned at 19
Qian Chen et al.
Mutation research, 638(1-2), 11-16 (2007-09-28)
Carbadox, a quinoxaline 1,4-dioxide derivative, is a known mutagen with its functional mechanism yet to be well defined. In the present study we used a shuttle vector assay in vitro to uncover the functional details of carbadox-induced mutagenesis in mammalian
Awais Ihsan et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 51, 330-336 (2012-10-16)
Quinoxaline-1,4-dioxides (QdNOs) are the potent heterocyclic N-oxides with interesting biological properties such as antibacterial, anticandida, antitubercular, anticancer and antiprotozoal activities. Here, we tested and compared the mequindox (MEQ) for mutagenic abilities in a battery of different short term tests according

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