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方案
≥95% (SDS-PAGE)
表单
aqueous glycerol solution
比活
≥1000 U/mg
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... CAPN1(823)
应用
人类钙蛋白酶 1 已用在一项研究中评估人类钙蛋白酶 1 和 9 的晶体结构是如何暗示各种作用和自抑制机制的。人钙蛋白酶 1 也已用于研究 N 杂环二肽醛（作为选择性钙蛋白酶抑制剂）的合成、生物学评估和分子模型研究。
生化/生理作用
胞质蛋白酶作为上游调节剂参与细胞骨架重塑、自噬和细胞凋亡。
钙蛋白酶 1 是含有 EF 手基序的中性钙依赖性半胱氨酸蛋白酶。蛋白酶由两个亚基组成；较大的亚基具有四个与木瓜蛋白酶和钙调蛋白同源的结构域。较小的亚基具有一个与钙调蛋白具有同源性的结构域。它被微摩尔水平的钙激活，因此也被称为微钙蛋白酶。它的激活导致细胞蛋白降解、神经元细胞变性和自身免疫性脱髓鞘疾病，例如多发性硬化。
物理属性
钙蛋白酶 1 是异二聚体钙激活的巯基蛋白酶。
单位定义
在25 °C 下，每分钟一个单位水解1皮摩尔的Suc-LLVY-AMC。
外形
在 20 mM 咪唑-HCl，5 mM β-巯基乙醇，1 mM EDTA，1 mM EGTA 和 30％ 甘油中的溶液。
抑制剂
产品编号
说明
价格
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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