生物来源
mouse
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
53103.111, monoclonal
表单
lyophilized powder
种属反应性
human
技术
flow cytometry: suitable using human PBMCs (1 μg/106 cells)
immunohistochemistry: 25 μg/mL using frozen human tissue sections
同位素/亚型
IgG2b
UniProt登记号
储存温度
−20°C
基因信息
human ... CCR6(1235)
mouse ... Ccr6(12458)
一般描述
Chemokine receptor CCR6 plays an important role in adaptive immunity, recruitment of CD4+ T cells and dendritic cells to sites of epithelial inflammation. It is expressed on leukocyte subsets of T cells, B cells, immature dendritic cells, neutrophils, monocytes and NKT cells. CCR6 binds the chemokine, CCL20 (macrophage inflammatory protein-3α) and induces proinflammatory signals such as TNF-α, IFN-γ and toll-like receptor agonists that in turn activate ERK1/2 and p38 MAPK pathways. CCR6 has been linked to autoimmune diseases of multiple sclerosis, rheumatoid arthritis, psoriasis and atherosclerosis. Monoclonal Anti-CCR-6 reacts with CCR-6 transfected cells and not with the parent cell line. The antibody shows no cross-reactivity with CCR-1, CCR-2, CCR-3, CCR-4, CCR-5, CCR-7, CXCR-1, CXCR-2, CXCR-3, CXCR-4 and STRL33 transfected cells.
特异性
The antibody reacts with human CCR-6 transfectant cells and not the parent cell line. The antibody shows no cross-reactivity with CCR-1, CCR-2, CCR-3, CCR-4, CCR-5, CCR-7, CXCR-1, CXCR-2, CXCR-3, CXCR-4 or STRL33.
免疫原
human CCR-6 transfected NSO mouse myeloma cells.
应用
Monoclonal Anti-CCR-6 antibody may be used for flow cytometry at a working concentration of 1μg/106 cells using human peripheral blood mononuclear cells. Antibody concentration of 25 μg/ml may be used for immunohistochemistry of frozen human tissue sections.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
制备说明
Purified using protein G.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Toshihiro Ito et al.
Experimental cell research, 317(5), 613-619 (2011-03-08)
Chemokines are key mediators of leukocyte recruitment during pathogenic insult and also play a prominent role in homeostasis. While most chemokine receptors bind to multiple chemokines, CCR6 is unique in that this receptor is one of only a few that
Iain Comerford et al.
BioEssays : news and reviews in molecular, cellular and developmental biology, 32(12), 1067-1076 (2010-10-19)
Chemokines (chemotactic cytokines) drive and direct leukocyte traffic. New evidence suggests that the unusual CCR6/CCL20 chemokine receptor/ligand axis provides key homing signals for recently identified cells of the adaptive immune system, recruiting both pro-inflammatory and suppressive T cell subsets. Thus
Wuzhou Wan et al.
Trends in cardiovascular medicine, 21(5), 140-144 (2012-06-27)
Atherosclerosis is a complex vascular pathology characterized in part by accumulation of innate and adaptive inflammatory cells in arterial plaque. Molecular mediators responsible for inflammatory cell accumulation in plaque include specific members of the chemokine family of leukocyte chemoattractants and
Evemie Schutyser et al.
Cytokine & growth factor reviews, 14(5), 409-426 (2003-09-02)
CCL20, alternatively named liver and activation-regulated chemokine (LARC), macrophage inflammatory protein-3alpha (MIP-3alpha) or Exodus-1, is the only chemokine known to interact with CC chemokine receptor 6 (CCR6), a property shared with the antimicrobial beta-defensins. The ligand-receptor pair CCL20-CCR6 is responsible
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