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C5438

Sigma-Aldrich

8-（4-氯苯硫基）-鸟苷 3′,5'-环单磷酸 钠盐

≥95% (HPLC), powder

别名:

8-pCPT-cGMP, pCPT-cGMP

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About This Item

经验公式（希尔记法）:
C16H14ClN5NaO7PS
CAS号:
51239-26-0
分子量:
509.79
MDL编号:
MFCD00674888
UNSPSC代码:
41106305
PubChem化学物质编号:
24892786
NACRES:
NA.77

方案

≥95% (HPLC)

表单

powder

颜色

white

溶解性

H2O: 25 mg/mL

储存温度

−20°C

SMILES字符串

[Na+].NC1=Nc2c(nc(Sc3ccc(Cl)cc3)n2[C@@H]4O[C@@H]5COP([O-])(=O)O[C@H]5[C@H]4O)C(=O)N1

InChI

1S/C16H15ClN5O7PS.Na/c17-6-1-3-7(4-2-6)31-16-19-9-12(20-15(18)21-13(9)24)22(16)14-10(23)11-8(28-14)5-27-30(25,26)29-11;/h1-4,8,10-11,14,23H,5H2,(H,25,26)(H3,18,20,21,24);/q;+1/p-1/t8-,10-,11-,14-;/m1./s1

InChI key

REEQGIQRCDWDRA-ZBMQJGODSA-M

相关类别

应用

8-（4-氯苯硫基）-鸟苷 3′,5‘-环状单磷酸钠盐已被用于激活血管平滑肌细胞（VSMC）中的GMP依赖性蛋白激酶（PKG）。

生化/生理作用

cGMP的膜渗透性类似物，不影响cGMP调节的磷酸二酯酶。 比8-Br-cGMP更有效的cGMP类似物，因为它具有更高的膜渗透性和更高的抗磷酸二酯酶水解能力。用作cGMP依赖性蛋白激酶（PKG）的选择性激活剂。被发现是一种非常有效的环状核苷酸门控通道激动剂。

特点和优势

《受体分类和信号转导》手册的PKA & PKG页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000353336
0000353336
SLCC7040
SLBX5098
SLBM7571V

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J Y Wei et al.
Journal of molecular neuroscience : MN, 10(1), 53-64 (1998-05-20)
Cyclic nucleotide-gated (CNG) channels are expressed in many cell types in both the nervous system and nonexcitable tissues. In order to understand the roles of cGMP-gated channels, and to distinguish actions of cGMP mediated through CNG channels from those through
Richard B Thorpe et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(9), R734-R743 (2013-03-01)
Chronic hypoxia attenuates soluble guanylate cyclase-induced vasorelaxation in serotonin (5-HT)-contracted ovine carotid arteries. Because protein kinase G (PKG) mediates many effects of soluble guanylate cyclase activation through phosphorylation of multiple kinase targets in vascular smooth muscle, we tested the hypothesis
Stainless steel ions stimulate increased thrombospondin-1-dependent TGF-beta activation by vascular smooth muscle cells: implications for in-stent restenosis
Pallero MA, et al.
Journal of Vascular Research, 47(4), 309-322 (2010)
Yang Chen et al.
Circulation research, 124(10), 1462-1472 (2019-04-02)
Acute kidney injury (AKI) has a high prevalence and mortality in critically ill patients. It is also a powerful risk factor for heart failure incidence driven by hemodynamic changes and neurohormonal activation. However, no drugs have been approved by the
M Suhasini et al.
Molecular and cellular biology, 18(12), 6983-6994 (1998-11-20)
Agents which increase the intracellular cyclic GMP (cGMP) concentration and cGMP analogs inhibit cell growth in several different cell types, but it is not known which of the intracellular target proteins of cGMP is (are) responsible for the growth-suppressive effects
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